Evaluation of intra-articular injection of bupivacaine in combination with morphine, methylprednisolone, or alone on pain after knee arthroscopy

Authors

  • Alizadeh, Ali Department of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  • Binazadeh, Idin Department of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  • Kayalha, Hamid Department of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  • Rastak, Sharam Department of Anesthesiology, Faculty of Paramedicine, Qazvin University of Medical Sciences, Qazvin, Iran
  • Shahamat, Hoda Department of Anesthesiology, Faculty of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran
  • Sofiabadi, Mohammad Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract:

Background and Aims: Knee arthroscopy is used to diagnose and treat intra-articular lesions. The control of acute pain after arthroscopy requires the use of a method with the least side effects and most efficacies. This study aimed to compare the sedative effect of bupivacaine in combination with morphine, methylprednisolone, or alone in knee arthroscopy after intra-articular injection. Materials and Methods: This clinical-randomized three-blind trial included 99 volunteer patients with knee arthroscopy. The patients were randomly divided into three groups of bupivacaine (0.5%), morphine (5 mg)+bupivacaine (0.5%), and methylprednisolone (40 mg)+bupivacaine (0.5%). At the end of the surgical operation, the intra-articular injection of the medications were performed, and the amount of postoperative pain was evaluated and recorded based on visual analog scale 6, 12, 18, and 24 h after injection. In addition, the reception of the injected analgesic within 24 h was recorded in this study. Data were analyzed using SPSS software (version 19) through ANOVA. Results: In all three groups, the pain intensity decreased significantly over time. The pain intensity of the methylprednisolone+bupivacaine and morphine+bupivacaine groups was similar at different postoperative periods; however, the pain intensity of these groups was significantly lower than that in the control group. In addition, consumption of the analgesics was significantly reduced in the methylprednisolone+bupivacaine group, compared to the other two groups. Conclusion: The results of this study showed that the intra-articular injection of methylprednisolone+bupivacaine and morphine+bupivacaine was more effective than bupivacaine alone in reduction of pain and the need for injectable analgesia.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

[Intra-articular analgesia with morphine, bupivacaine or fentanyl after knee video-arthroscopy surgery.].

BACKGROUND AND OBJECTIVES Methods to promote knee pain analgesia without impairing motor function have been widely researched. This study aimed at comparing intra-articular morphine, bupivacaine, and fentanyl analgesic effects (as compared to saline solution), after knee video-arthroscopy. METHODS Participated in this study 60 patients who were randomly distributed in four groups: GI (n = 15)...

full text

Intra-articular morphine and/or bupivacaine after total knee replacement.

The postoperative analgesic effects of intra-articular injections of bupivacaine and/or morphine were examined prospectively in 437 patients who had total knee replacement for osteoarthritis. They were divided randomly into four groups. Group I received 10 mg of morphine (1 ml) and 9 ml of saline, group II received 10 ml of bupivacaine (2.5 mg/ml), group III received 10 ml of saline, and group ...

full text

Intra-articular bupivacaine or bupivacaine and morphine after ACL reconstruction

OBJECTIVE Reconstructive surgery of the ACL is one of the most commonly performed surgeries today and the control of postoperative pain is part of the priorities of the surgeon. Within the arsenal of analgesia we have the intra-articular application of drugs, and the most studied one is bupivacaine with or without morphine. This study compared the application of bupivacaine with or without morp...

full text

A Single-Dose Intra-Articular Morphine plus Bupivacaine versus Morphine Alone following Knee Arthroscopy: A Systematic Review and Meta-Analysis

OBJECTIVES The purpose of this study was to compare the efficacy and safety of a single-dose intra-articular morphine plus bupivacaine versus morphine alone in patients undergoing arthroscopic knee surgery. METHODS Randomized controlled trials comparing a combination of morphine and bupivacaine with morphine alone injected intra-articularly in the management of pain after knee arthrocopic sur...

full text

مقایسه اثرات تزریق داخل مفصلی پتیدین با بوپیواکایین 5/0% پس از پایان آرتروسکوپی زانو بر میزان بی‌دردی بعد از عمل

    Background & Aim: One of the methods of controlling pain after knee arthroscopy is intra articular injection of morphine with or without local anesthesia. Pethidine is an opioid that also has week local anesthetic effect. The aim of this study was to compare the analgesic effect of intra-articular pethidine, bupivacaine and their combination at the end of knee arthroscopy on postoperative p...

full text

Morphine for Pain Relief after Knee Arthroscopy

We performed a randomised double-blind controlled study in patients undergoing elective knee arthroscopy to assess the effect of intra-articular morphine on postoperative pain relief. Patients in the study group (n = 10) received 5 mg of morphine in a 25 ml dilution intra-articularly while those in the control group (n 10) received 25 ml of saline. Postoperative pain was assessed at intervals b...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 27  issue 4

pages  314- 322

publication date 2020-12

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023