Evaluation of in vitro anti-leishmaniasis activity of three marine species from Persian Gulf

Authors

Abstract:

Introduction: Recently, the drugs with marine resources have been considered due to the lower costs and greater compatibility with patients. In the present study, the extracts of three marine organisms from the Persian Gulf; Holothuris parva, Ophiocoma scolopendrina and Echinometra matheai, were prepared and evaluated their in vitro anti-leishmaniasis effects. Materials & Methods: All three marine organisms were collected from the coastal waters of Bushehr province and after separating their shell from the viscera, were extracted by percolation method using different solvents. All prepared extracts were evaluated for anti-leishmanial activity on Leishmania major promastigotes in vitro. Results: Statistical analysis showed that the extract type and the concentrations used (dose) had a very significant effect. Also, the dual interactions of extract and dose, extract and solvent, as well as the triple interaction of extract, solvent and dose were significant on the inhibitory rate. The highest anti-leishmanial activity was related to methanolic extracts of Holothuria Parva's shell (88.65%) and Echinometra matheai's viscera (87.48%) at 800μg/ml concentrations, and the lowest activity was obtained in aqueous extract of Ophiocoma scolopendrina (43.01%) at 20μg/ml concentration. Conclusion: Considering the anti-leishmanial effects of all three marine organisms studied in this research, and the presence of their rich reserves in the Persian Gulf in another way, by performing a series of complementary studies in vivo and identifying the effective compounds of these extracts, efficient steps can be taken to produce effective drugs for the control and treatment of cutaneous leishmaniasis.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

In vitro investigating of anticancer activity of focuxanthin from marine brown seaweed species

Breast cancer is the most common cancer type among women all over the world. Chemotherapy is the use of anticancer medicines for treating cancer but it has many side effects and cells may become resistant to these chemical medicines. Therefore, finding new compounds of natural origin could be a promising solution to this problem. The aim of the current study was to evaluate anticancer activity ...

full text

Evaluation of in vitro anti-Leishmanial activity of some brown, green and red algae from the Persian Gulf.

BACKGROUND AND OBJECTIVES Leishmaniasis is a protozoan parasitic disease which is transmitted by the female Phlebotomus sand fly and is prevalent in four continents.The first-choice treatment for the leishmaniasis is pentavalent antimonials, which are potentially toxic and often ineffective and use of them exhibit therapeutic failure. These pharmaceutical problems point towards the need to deve...

full text

Cytotoxic effects of three Persian Gulf species of Holothurians

Background: Pharmaceutical industries around the world are struggling for finding new approaches to fight cancer and many researchers are involved in this process to find new drug candidates. Aims: The current study aimed at investigating the new marine natural products with anticancer potential from the three Persian Gulf Holothuria sea cucumbers. <st...

full text

Isolation and evaluation of cytotoxic and antioxidant activity of bioactive metabolites of cultured actinobacteria in Persian Gulf marine sediments

Screening bacteria for bioactive compounds is the first step in the drug discovery programs. The aim of the present research was to achieve cytotoxic and antioxidant metabolites from actinobacteria of Persian Gulf sediments and to investigate the effects of combinations of seven treatments and six isolation media on the selective isolation process. A total of 395 actinobacterial isolates were c...

full text

skopos theory and translating strategies of csis in translaed literary texts from english into persian

abstract translation has become a cultural act which plays a significant role in human life. with the emergence of functional translation theories, and skopos theory in particular, translation has been considered as a purposeful, interpersonal and intercultural activity which is produced for particular recipients and directed by a specific purpose. this purpose determines the translatio...

15 صفحه اول

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 25  issue 4

pages  0- 0

publication date 2020-08

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023