Evaluation of an Infant with Cholestasis and Congenital Hypopituitarism

Authors

  • Manoochehr Karjoo Pediatrician and Gastroenterologist Upstate Medical University, Syracuse New York USA.
  • Sara Karjoo Assistant professor, Department of Pediatric Gastroenterology, Johns Hopkins All Children’s Hospital, St Petersburg, Florida, USA.
  • Wahhaj Beg Department of Ecology and Evolutionary Biology, University of Connecticut, Connecticut, USA.
Abstract:

We are reporting an infant with persistent abnormal liver function, neonatal jaundice, and intermittent hypoglycemia. Evaluation confirmed congenital hypopituitarism, in the absence of congenital anomalies and midline defect. His jaundice and abnormal liver function improved after treatment with Levothyroxine and hydrocortisone.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Neonatal cholestasis and hypopituitarism 787 Neonatal cholestasis and hypopituitarism

Optic nerve hypoplasia with hypopituitarism and intact septum pellucidum is a variant of septo-optic dysplasia or deMorsier's syndrome.' Although neonatal jaundice has been seen with this syndrome, the association with severe prolonged cholestatic jaundice has not been emphasised. We describe three patients who presented with cholestatic jaundice and were found to have optic nerve hypoplasia an...

full text

Neonatal cholestasis and hypopituitarism.

We read with interest the paper by Kaufman et al' on neonatal cholestasis and hypopituitarism. We have been treating a similar patient whose problems were complicated by diabetes insipidus of pituitary origin. She was referred from another hospital at the age of 1 month for assessment of secondary hypothyroidism, cholestatic jaundice, temperature instability, and microcephaly. She was born at 4...

full text

A congenital hypopituitarism infant presented with unexplained hypoglycemia

Congenital hypopituitarism may present with non-specific symptoms, so it is difficult to diagnose in newborn infants. If hypopituitarism cannot be recognized, recurrent hypoglycemia can occur, leading to permanent brain damage. At 14 hours of age, a 2.9 kg, female infant, born at 35 weeks of gestation, presented with respiratory distress caused by hypoglycemia. She had no risk factor to develop...

full text

Neonatal cholestasis and hypopituitarism 787

Optic nerve hypoplasia with hypopituitarism and intact septum pellucidum is a variant of septo-optic dysplasia or deMorsier's syndrome.' Although neonatal jaundice has been seen with this syndrome, the association with severe prolonged cholestatic jaundice has not been emphasised. We describe three patients who presented with cholestatic jaundice and were found to have optic nerve hypoplasia an...

full text

Congenital neuroblastoma presented with cholestasis and huge hepatomegaly

This case report is about a 28-day-old neonate that had abdominal distention and massive hepatomegaly since 15th days of birth. First, he was normal, and he had not any sign and symptom of sepsis. At admission, he was about twelve days, he had a rapid progressive presentation of sepsis and unfortunately, he passed away. His liver biopsies manifested the neuroblastoma.

full text

Optic nerve aplasia in an infant with congenital hypopituitarism and posterior pituitary ectopia.

type transthyretin as well as other fibrillar proteins. To our knowledge, this is the first case report of vitreoretinal amyloidosis in the absence of transthyretin mutations. In addition, no signs of systemic amyloidosis suggestive of FAP were evident 7 years after the patient’s initial presentation, although we cannot exclude the possibility of a subclinical level of amyloid deposition in oth...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 5  issue 10

pages  5881- 5886

publication date 2017-10-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023