Engineering Nano-aggregates: β-Cyclodextrin Facilitates the Thiol-Gold Nanoparticle Self-Assembly

Authors

  • D Badmapriya Department of Chemistry, School of Advanced Sciences, Vellore Institute of Technology, Vellore, Tamil Nadu, India
  • Israel Enoch Department of Chemistry, 4Nanotoxicology Research Lab, Department of Nanoscience, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamil Nadu, India
  • Sameena Yousuf Department of Chemistry, Sri Shakthi Institute of Engineering and Technology, Coimbatore 641062, Tamil Nadu, India |Department of Chemistry, 4Nanotoxicology Research Lab, Department of Nanoscience, Karunya Institute of Technology and Sciences, Coimbatore 641114, Tamil Nadu, India
Abstract:

The structure and morphology of nonmaterial formed by colloidal synthesis represent a subject of interest as it is a factor deciding the physicochemical properties and biological applications of nanostructures. Among various nanoparticles, gold can develop fractal assembled patterns. Herein, we report a nano-aggregate of a thiol-on-gold self-assembled structure and the influence of β-cyclodextrin on the self-assembly. The host: guest association of the 5-(4-pyridyl)-1,3,4-oxadiazole-2-thiol is studied using UV-visible, fluorescence spectroscopy and molecular modelling analysis. In free form unbound to gold nanoparticles, the thiol compound forms a cyclodextrin complex with a 1: 1 stoichiometry. The thiol assembled on gold nanoparticles, aggregating to constitute irregular patterns. β-cyclodextrin encapsulates the thiol-on-gold nanoparticles and their morphology changes. The influence of β-cyclodextrin on the aggregation of the thiol guest molecule and the morphology of the thiol-on-gold nanostructure is discussed. The non-covalent complex made up by the thiol molecule with cyclodextrin plays a vital role in tuning the structure of the nanostructure when assembled on gold nanoparticles.The study will open up a significant method in the approach towards site specific drug delivery via a physical encapsulation.

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Journal title

volume 9  issue 4

pages  751- 760

publication date 2019-10-01

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