Effects of Estrogen and Progesterone on Behavioral Impairment and Neuronal Death in Ovariectomized Rats Induced by Methamphetamine

Authors

  • Ghazvini, Hamed Assistant Professor, Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Mellati, Amir Assistant Professor, Department of Tissue Engineering, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Elyasi, Leila Assistant Professor, Department of Anatomy, Neuroscience Research Center, Faculty of Medicine, Golestan University of Medical Sciences, Gorgan, Iran
  • Ghalehnoei, Hossein Assistant Professor, Department of Medical Biotechnology, Molecular and Cell Biology Research Center, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Hosseini, Morteza Medical Student, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Khodamoradi, Mehdi Assistant Professor, Substance Abuse Prevention Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Rafaiee, Raheleh Assistant Professor, Department of Neuroscience, Faculty of Advanced Technologies in Medicine, Mazandaran University of Medical Sciences, Sari, Iran
  • Siahposht Khachaki, Ali Assistant Professor, Psychiatry and Behavioral Sciences Research Center, Addiction Institute, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:

Background and purpose: Methamphetamine (METH) is one of the most powerful drugs that leads to many cognitive and behavioral side effects such as anxiety. On the other hand, studies have shown that ovarian hormones such as estrogen and progesterone have neuroprotective effects on a wide range of cognitive and behavioral disorders. The aim of this study was to investigate the role of estrogen and progesterone on anxiety-like behaviors, body temperature, brain edema, and neuronal death induced by neurotoxic regimen of methamphetamine. Materials and methods: This study was performed in 48 ovariectomized rats divided into six groups including: control, METH (6mg / kg), vehicle (sesame oil), METH + estrogen (1mg / kg), METH + progesterone (8mg / kg), and METH + estrogen + progesterone. Body temperature and anxiety-like behaviors were investigated, then, the animals were killed and brain tissues were harvested to evaluate brain edema and neuronal death in hippocampal CA1. Results: Body temperature, brain water content, motor activity, and anxiety-related behaviors significantly increased in animals that received METH (P<0.001), but, treatment with estrogen and progesterone attenuated motor activity, and anxiety-related behaviors induced by METH. Brain edema, body temperature, and neuronal cell death in hippocampal CA1 area partially decreased in METH+estrogen and METH + progesterone groups. Conclusion: This study suggests that ovarian hormones such as estrogen and progesterone are effective in improving behavioral deficits and neuronal death induced by METH in ovariectomized rats.  

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Journal title

volume 30  issue 186

pages  1- 12

publication date 2020-07

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