Effects of Bunium persicum (Boiss.) Essential Oil on the Contractile Responses of Smooth Muscle (An in vitro Study)
Authors
Abstract:
Bunium persicum (Boiss.) is an economically important medicinal plant growing wild in arid regions in Iran. The essential oil of B. persicum (EOBP) was extracted using hydrodistillation. A total of eighteen compounds, representing 96.14 % of the oil was identified by gas chromatography/mass spectrometry (GC/MS).The main compounds were cuminaldehyde (23.04 %), gamma-terpinene (14.48 %), trans-3-Caren-2-ol (12.51 %), acetic acid (10.90 %) and 1,3,8 -p- menthatriene (7.89 %). The effects of 0.1 to 1000 g mL-1 EOBP on ruminal and abomasal smooth muscle of twenty-four healthy sheep and ileum preparations of six rats were assessed in vitro. Ruminal preparations showed relaxation (P < 0.05) when exposed to 100 - 1000 g mL-1 concentrations of EOBP. In the isolated abomasal preparations, EOBP (0.1 - 1 g mL-1) represented a weak spasmogenic effect followed by relaxation. The spontaneous contraction of abomasal smooth muscles was completely abolished with a high dose (1000 g mL-1) of EOBP. Five-minute incubation with EOBP, significantly (P < 0.05) inhibited Ach-induced contraction in higher doses on both tissues. In contrast, rat ileum only showed dose-dependent relaxation effect, and pre-incubated tissues with EOBP, decreased the Ach-induced contraction. The data indicated that the plant contained spasmogenic and spasmolitic constituents. The results also showed that the EOBP profoundly alters gastrointestinal smooth muscle contraction in a dose-dependent and tissue-specific manner.
similar resources
effects of bunium persicum (boiss.) essential oil on the contractile responses of smooth muscle (an in vitro study)
bunium persicum (boiss.) is an economically important medicinal plant growing wild in arid regions in iran. the essential oil of b. persicum (eobp) was extracted using hydrodistillation. a total of eighteen compounds, representing 96.14 % of the oil was identified by gas chromatography/mass spectrometry (gc/ms).the main compounds were cuminaldehyde (23.04 %), gamma-terpinene (14.48 %), trans-3-...
full textEfficacy of the Bunium persicum (Boiss) Essential Oil against Acute Toxoplasmosis in Mice Model
BACKGROUND We evaluated the in vivo activity of Bunium persicum (Boiss) essential oil on infected mice with acute toxoplasmosis. METHODS To evaluate prophylactic effects, male NMRI mice received B. persicum essential oil at the concentrations of 0.05 and 0.1 mL/kg for 14 days. After 24 h mice were infected intraperitonealy with 1×10(4) tachyzoites of T. gondii, RH strain. In order to investig...
full textAntifungal effect of essential oil of Bunium persicum on Candida albicans, In vitro study
Introduction: Bunium persicum is a gramine plant from Umbelliferae family. Candida albicans is a kind of yeast known as normal flora of skin and gastrointestinal tract (GIT), respiratory and genitourinary (GU) mucosa. This fungi makes disease in immunodeficient individuals. The aim of this study was to assess the antifungal effect of essential oil of Bunium persicum on Candida albicans. Methods...
full textInhibitory Effect of Bunium persicum Boiss Essential Oil on Castor-OilInduced Diarrhea
Background & Aims: Bunium persicum Boiss. Belongs to Apiaceae family and its fruit contains high level of essential oils used as native medicinal plant in traditional medicine. Methods: The essential oil of Bunium persicum (EOBP) was extracted by Clevenger apparatus using hydrodistillation. Lethal dose, 50% (LD50) was calculated based on Lorke’s method. Effects of EOBP (20- 80 mg/kg) on upper g...
full textthe effect of e-64 on the developmental competence of sheep cocs during in vitro maturation
in the present study, the effect of e-64 at different concentrations (0.5, 1, 5 and 10 µm) added to (1) the ivm medium on oocyte nuclear maturation and developmental competence of ovine oocytes, and (2) to the ivc medium on embryonic development of ovine embryos were investigated.
My Resources
Journal title
volume 2 issue 2
pages 87- 96
publication date 2011-06-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023