Early Renal Histological Changes in Alloxan-Induced Diabetic Rats
Authors
Abstract:
Diabetes mellitus is a progressive disease. Most investigators have focused on glomerular changes in diabetic kidney and non-glomerular alterations have been less attended. The present study has been conducted to find early non-glomerular histological changes in diabetic renal tissue. Twenty male Wistar rats weighting 200-250 g were used for the diabetic group. Diabetes mellitus was induced by single injection of Alloxan. After 8 weeks, paraffin embedded blocks of kidneys were prepared for evaluating the histological changes due to diabetes. Histological study showed the deposit of eosinophilic materials in the intermediate substantial of medulla and thickening of renal arterial wall in the kidney of 70% of diabetic rats. The average weight of kidneys increased when compared to non diabetic animals. Furthermore, the amount of blood flow in arteries of all diabetic kidneys has been enhanced. The present study demonstrates some early renal histological changes in diabetes mellitus which were earlier compared to those reported previously. Diabetic nephropathy is a progressive disease and renal care design can help better prognosis achievement.
similar resources
early renal histological changes in alloxan-induced diabetic rats
diabetes mellitus is a progressive disease. most investigators have focused on glomerular changes in diabetic kidney and non-glomerular alterations have been less attended. the present study has been conducted to find early non-glomerular histological changes in diabetic renal tissue. twenty male wistar rats weighting 200-250 g were used for the diabetic group. diabetes mellitus was induced by ...
full textProtective effects of oleuropein against renal injury oxidative damage in alloxan-induced diabetic rats; a histological and biochemical study
BACKGROUND Oleuropein is a potent antioxidant and free-radical scavenger with antiinflammatory properties. OBJECTIVES In the present study, we evaluated the protective effects of oleuropein on myeloperoxidase (MPO) activity, nitrite, urea, creatinine and glomerulosclerosis in alloxan-induced type 1 diabetic rats. MATERIALS AND METHODS Thirty Sprague-Dawley male rats were randomly divided in...
full textHistological changes in the pancreas following administration of ethanolic extract of Alchornea cordifolia leaf in alloxan-induced diabetic Wistar rats.
Twenty-four wistar rats weighing between 150 and 170 g were used in this research work. They were divided into four groups A, B, C, and D of six rats each. Diabetes was induced in Groups B, C, and D using a single intraperitoneal injection of 150 mg/kg of Alloxan after an overnight fast. Group A served as the normal control while Group B served as the diabetic control and each received 0.5 ml o...
full textCrataegus monogyna extract on renal histopathological changes in diabetic rats
Renal complications is considered as important cause of mortality in diabetic patients. This study investigated the effect of hydroalcoholic extract of C. monogyna on renal histopathological changes in diabetic rats. In this experimental study 40 male Wistar rats were divided into 5 groups (n=8) including control (receiving normal saline), diabetic (receiving streptozotocin), treatment groups ...
full textEarly Biochemical Changes in Renal Status of Diabetic Rats
Aim: The aim of this study was to compare the diagnostic value of serum creatinine and cystatin c in detection of minor changes at early stages of development of diabetic kidney disease. Background: Loss of kidney function is grossly under diagnosed due to the inherent weakness in the traditional kidney function markers, and cumbersome and uneconomical nature of the gold standard. The imperativ...
full textMy Resources
Journal title
volume 3 issue None
pages 11- 15
publication date 2014-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023