Differential Expression of CXCL1, CXCL9 CXCL10 and CXCL12 Chemokines in Alopecia Areata
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Abstract:
Background: Alopecia Areata (AA) is a non-scarring, autoimmune disorder which causes hair loss. Inflammatory reactions are involved in hair loss of the scalp and/or body. The involvement of chemokine receptors in the pathogenesis of AA is well defined among which, CXCL1 acts on neutrophils and CXCL9, CXCL10 and CXCL12 and serve as T lymphocytes recruiters. Objective: To study the serum levels of ELR+ and ELR- CXCL1, CXCL9, CXCL10 and CXCL12 in the patients suffering from AA and healthy controls. Methods: The study population of consisted of 30 patients suffering from AA and 30 healthy controls. Serum concentrations of CXCL1, CXCL9, CXCL10 and CXCL12 were measured using enzymelinked immunosorbent assay (ELISA). Results: Current results showed that AA patients had significantly elevated serum levels of CXCL9 and CXCL10 in comparison to controls (p
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Differential expression of CXCL1, CXCL9, CXCL10 and CXCL12 chemokines in alopecia areata.
BACKGROUND Alopecia Areata (AA) is a non-scarring, autoimmune disorder which causes hair loss. Inflammatory reactions are involved in hair loss of the scalp and/or body. The involvement of chemokine receptors in the pathogenesis of AA is well defined among which, CXCL1 acts on neutrophils and CXCL9, CXCL10 and CXCL12 serve as T lymphocytes recruiters. OBJECTIVE To study the serum levels of EL...
full textdifferential expression of cxcl1, cxcl9 cxcl10 and cxcl12 chemokines in alopecia areata
background: alopecia areata (aa) is a non-scarring, autoimmune disorder which causes hair loss. inflammatory reactions are involved in hair loss of the scalp and/or body. the involvement of chemokine receptors in the pathogenesis of aa is well defined among which, cxcl1 acts on neutrophils and cxcl9, cxcl10 and cxcl12 and serve as t lymphocytes recruiters. objective: to study the serum levels o...
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Caroline G. McPhee1, F. Jason Duncan2, Kathleen A. Silva1, Lloyd E. King Jr.3, Harm HogenEsch4, Derry C. Roopenian1, Helen B. Everts2, and John P. Sundberg1,3 1The Jackson Laboratory, Bar Harbor, ME 2Department of Nutrition, The Ohio State University, Columbus, OH 3Division of Dermatology, Vanderbilt University, Nashville, TN 4Department of Comparative Pathobiology, Purdue University, West Lafa...
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Journal title
volume 10 issue 1
pages 40- 46
publication date 2013-03-01
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