Determination of Haptoglobin Genotype in an Iranian Population with Idiopathic Generalized Epilepsy
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Abstract:
Background: Haptoglobin (Hp) is a plasma α2-sialoglycoprotein that contains alpha and beta chains. It displays in three common phenotypes, Hp1-1, Hp2-1, and Hp2-2. Proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. Haptoglobin expressed by the Hp2-2 genotype has lower hemoglobin-binding capacity than Hp1-1 or Hp2-1 and is associated with idiopathic generalized epilepsy. Methods: To determine polymorphism in haptoglobin genes in patients with idiopathic generalized tonic-clonic seizures, 42 men, 42 women, and 50 controls were selected for this study. Genomic DNA was extracted from blood and studied by polymerase chain reactions (PCR). Results: The amplified fragments for the Hp1-1 and Hp2-2 genotypes were 1757 and 3481 base pairs (bp) respectively, and the Hp2-1 genotype had both fragments, in addition to a 349-bp fragment. The distribution of the three major Hp phenotypes in epilepsy patients was 28.6 (1-1), 38.1 (2-1), and 33.3% (2-2) in the men, and 31 (1-1), 40.5 (2-1), and 28.6% (2-2) in the women. The distribution of Hp genotypes in controls was 22 (1-1), 40 (2-1), and 38% (2-2). Conclusion: We show that all Hp genotypes participate in idiopathic generalized epilepsy.
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Determination of haptoglobin genotype in an Iranian population with idiopathic generalized epilepsy.
BACKGROUND Haptoglobin (Hp) is a plasma α2-sialoglycoprotein that contains alpha and beta chains. It displays in three common phenotypes, Hp1-1, Hp2-1, and Hp2-2. Proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. Haptoglobin expressed by the Hp2-2 genotype has lower hemoglobin-binding capacity than Hp1-1 or Hp2-1 ...
full textdetermination of haptoglobin genotype in an iranian population with idiopathic generalized epilepsy
background: haptoglobin (hp) is a plasma α2-sialoglycoprotein that contains alpha and beta chains. it displays in three common phenotypes, hp1-1, hp2-1, and hp2-2. proteins expressed by polymorphic genes have grossly different molecular sizes resulting in different diffusion rates in the brain. haptoglobin expressed by the hp2-2 genotype has lower hemoglobin-binding capacity than hp1-1 or hp2-1...
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Journal title
volume 3 issue 2
pages 51- 55
publication date 2015-05
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