Cytotoxic Effects of Five Species of Inula Against Some Tumor Cell Lines

Authors

  • Farzaneh Naghibi Traditional Medicine and Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  • Mahmood Mosaddegh Traditional Medicine and Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  • Maryam Moghadam Traditional Medicine and Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, Iran
  • Syyed Naser Ostad Department of Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
Abstract:

     The chloroform soluble fractions of ethanolic extracts of five Inula belonging to the Compositae family were evaluated for cytotoxic activity against five different cell lines including CACO2 (human colon adenocarcinoma), MCF7 (human breast adenocarcinoma), HEPG2 (human hepatocellular carcinoma), VERO (green African monkey kidney) and WEHI164 (balb c mouse fibrosarcoma). Cytotoxicity was assessed by MTT assay. Among these five species, Inula oculus christi, exhibited better cytotoxic effects.  

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

cytotoxic effects of five species of inula against some tumor cell lines

the chloroform soluble fractions of ethanolic extracts of five inula belonging to the compositae family were evaluated for cytotoxic activity against five different cell lines including caco2 (human colon adenocarcinoma), mcf7 (human breast adenocarcinoma), hepg2 (human hepatocellular carcinoma), vero (green african monkey kidney) and wehi164 (balb c mouse fibrosarcoma). cytotoxicity was assess...

full text

Cytotoxic Effects of Essential Oils and Extracts of some Mentha species on Vero, Hela and Hep2 Cell Lines

Background: Mentha species are widely used in traditional medicine mostly as anti-flatulence. Nowadays, their usage as flavor and preservative in food, cosmetic and pharmaceutical industries has been developed. Moreover, cytotoxic effects of some Mentha species have been reported. Objective: In this study, cytotoxic properties of Mentha piperita, M. spicata, M. aquatica, M. crispa, M. puleg...

full text

Evaluating cytotoxic effects of recombinant fragaceatoxin C pore forming toxin against AML cell lines

Objective(s): Current therapeutic strategies for cancer are associated with side effects and lack of specificity in treatments. Biological therapies including monoclonal antibodies and immune effectors have been the subject of multiple research projects. Pore-forming proteins may become the other biological strategy to overcome the problems associated with current treatments. But detailed mecha...

full text

Bioassay Guided Fractionation of Allium austroiranicum by Cytotoxic Effects against Ovary and Cervical Cancer Cell Lines

Background and objectives: Cancer is a major health problem in the world. The aim of this study was to extract the flowers of Allium austroiranicum used by Iranian people as a condiment or for its medicinal effects followed by bioassay guided fractionation of the extracts and fractions, using anti-proliferative effects against ovarian and cervical cancer cells. <strong...

full text

Cytotoxic activity of styrylchromones against human tumor cell lines.

A total of 6 newly-synthesized styrylchromones (SC-1 approximately SC-6) were compared for their cytotoxic activity against three normal oral human cells (gingival fibroblast HGF, pulp cell HPC, periodontal ligament fibroblast HPLF) and four human tumor cell lines (squamous cell carcinoma HSC-2, HSC-3, submandibular gland carcinoma HSG, promyelocytic leukemia HL-60). All compounds showed higher...

full text

Cytotoxic activity of azulenequinones against human oral tumor cell lines.

We investigated twenty-seven azulenequinone derivatives for their relative cytotoxicity against three human normal cell lines (HGF, HPC, HPLF) and four human tumor cell lines (HSG, HSC-2, HSC-3, HL-60). Parent 1,5-azulenequinone showed potent and some tumor-specific cytotoxicity. Halogenated derivatives of 1,5- and 1,7-azulenequinone showed potent cytotoxicity, but lower tumor-specific cytotoxi...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 2  issue 4

pages  203- 208

publication date 2006-10-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023