Cytokine Production in Hymenolepis Nana Infection

Authors

  • Aboulghasem Ajami Department of Immunology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran
  • Alireza Rafiei Department of Immunology, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:

Background: Although many experimental studies provide convincing evidence that type II immunity is protective against helminths, recent data in mice demonstrate that Th1 is also impor-tant in some cestodes like Hymenolepis nana. Objective: To identify the role of Th1 and Th2 lymphocytes in immunity against H. nana, the levels of IL-12, IFNγ, IL-5, and IL-13 were de-termined in serum of humans infected with this cestode. Methods: A total of 31 patients (case) with H. nana infection and 30 clinically healthy individuals (control) was included in this study. Measurements of IL-12, IFNγ, IL-13 and IL-5 in serum samples were performed by solid-phase sandwich enzyme linked immunosorbant assay. Differential leukocyte count was also done. T test, Mann Whitney U test and Wilcoxan W test were used for data analysis. Results: The mean concentrations of IFNγ, IL-12 and IL-5 in the sera of patients with H. nana infection were higher than the control group, but only the differences between the concentrations of IFNγ (p

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Cytokine production in Hymenolepis nana infection.

BACKGROUND Although many experimental studies provide convincing evidence that type II immunity is protective against helminths, recent data in mice demonstrate that Th1 is also important in some cestodes like Hymenolepis nana. OBJECTIVES To identify the role of Th1 and Th2 lymphocytes in immunity against H. nana, the levels of IL-12, IFNgamma, IL-5, and IL-13 were determined in serum of huma...

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cytokine production in hymenolepis nana infection

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Journal title

volume 4  issue 4

pages  236- 240

publication date 2007-12-01

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