Cytogenetic findings in couples with fertility problems
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Abstract:
Background: Chromosomal aberrations can be one of the causes of fertility problems, including infertility or frequent abortions. Identification of chromosomal aberrations by clinical diagnostic techniques has been primarily performed through standard karyotyping. In this screening, the prevalence of these disorders were checking in individuals with fertility problems from west population of Iran. Methods: A prospective cytogenetic study was conducted on 200 cases (124 women (28.1±5) and 76(30.7±5) men with fertility problems and age average 30.81±5 for chromosomal abnormalities using routine karyotyping. Results: Types of chromosomal anomalies were observed in 62(31%) individuals (35 and 27 patients with RPL and infertility, respectively). Among the chromosomal aberrations, the prevalence of translocations, deletions, inversions, duplications and insertions were 40.32% (25), 22.6% (14), 17.74% (11), 9.7% (6) and 9.7% (6), respectively. The most abnormal disorder was belonging to chromosomal displacement or translocation (40.32%). Conclusion: The high prevalence of chromosomal abnormality (31%) in population studied was shown genetic counseling should be providing to the family members to explain the recurrence risk as well as the need for prenatal diagnosis in subsequent pregnancies and management of patients by collected data bank.
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Journal title
volume 26 issue 3
pages 31- 39
publication date 2019-05
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