Crataegus monogyna extract on renal histopathological changes in diabetic rats

Renal complications is considered as important cause of mortality in diabetic patients. This study investigated the effect of hydroalcoholic extract of C. monogyna on renal histopathological changes in diabetic rats. In this experimental study 40 male Wistar rats were divided into 5 groups (n=8) including control (receiving normal saline), diabetic (receiving streptozotocin), treatment groups (receiving STZ and C. monogyna extract at 100, 200 and 400 mg/kg). Treatments with drug and extract were performed 72 hours after intra-peritoneal injection of a single-dose of STZ (60 mg/kg). Glucose, kidney factors urea and ceratinine in serum were meseared and then kidney tissue was removed under deep anesthesia and used for histopathological studies. The amount of glucose increased on day 21 after treatment with extract C. monogyna and the level of urea in all treatment groups with extract increased compared to diabetic group. The dose of 100 and 400 mg / kg of extract reduced the creatinine level significantly compared to the diabetic group. In the diabetic group, complete destruction of the renal tissue in cortex and complete degeneration and 100% necrosis of the nephrons were observed. In diabetic rats treated with C. monogyna extract, kidney tissue was normal and no renal bleeding and necrosis were observed, and kidney cysts were normal. C. monogyna extract was effective in preventing renal tissue damage due to diabetes.