Comparison between Brain Natriuretic Peptide and Calcitonin Gene Related Peptide in Children with Dilated Cardiomyopathy

Authors

  • Alireza Teimouri Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
  • iraj shahramian Department of Pediatric, Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
  • Noor Mohammad Noori Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
Abstract:

Background: Dilated cardiomyopathy (DCM) is revealed with the left ventricular dilatation and systolic dysfunction. This study was performed to determine the level of Calcitonin Gene Related Peptide (CGRP) and Brain Natriuretic Peptide (BNP) in children with dilated cardiomyopathy and controls and comparison of these two biomarkers in patients. Materials and Methods: This case-control study was performed from April 2014 to March 2015 on patients with DCM. The levels of BNP and CGRP were measured by ELISA and final amounts of biomarkers were compared with echocardiographic finding.37 DCM patients compared with 30 healthy children selected randomly from those who referred to the hospital for routine checkup. Results: In this study the mean age was 10.567± 5.50 and 12.135 ± 4.626 years for controls and cases, respectively (P=0.321). The majority of echocardiography indices in the left and right heart had different means in case and controls (P

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Journal title

volume 5  issue 9

pages  5693- 5707

publication date 2017-09-01

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