Comparing Serum Levels of Th17 and Treg Cytokines in Women with Unexplained Recurrent Spontaneous Abortion and Fertile Women

Authors

  • AboTaleb Saremi Sarem Fertility and Infertility Research Center (SAFIR) and Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran
  • Ahad Zare Sarem Fertility and Infertility Research Center (SAFIR) and Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran
  • Fatemeh Pak Cancer Research Center and Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, Iran,
  • Javad Arasteh Department of Biology, Faculty of Basic Sciences, Islamic Azad University Central Tehran Branch, Tehran,
  • Majid Mirmohammadkhani Research Center for Social Determinants of Health, Semnan University of Medical Sciences, Semnan, Iran
  • Narges Roomandeh Student Research Committee and Department of Immunology, Faculty of Medicine, Semnan University of Medical Sciences, Semnan, |Sarem Fertility and Infertility Research Center (SAFIR) and Sarem Cell Research Center (SCRC), Sarem Women’s Hospital, Tehran, Iran
  • Parviz Kokhaei Cancer Research Center and Department of Immunology, Faculty of Medicine|Immune and Gene Therapy Lab, Cancer Centre Karolinska, Karolinska University Hospital, Stockholm, Sweden
Abstract:

Background: Increased evidences have shown that unexplained recurrent spontaneous abortion (URSA) is associated with inflammatory responses and breakage of immunological autotolerance. Therefore, the balance between Th17 and Treg cells may elucidate the pathophysiology of URSA. Objective: To investigate the serum concentration of regulatory and inflammatory cytokines associated with Treg and Th17 in both normal and URSA females. Methods: Forty-six women with URSA and 28 non-pregnant control women with at least one successful pregnancy were included. Serum was obtained from both groups and stored at -70°C. The serum concentrations of IL-17, IL-21, IL-22, IL-10, and TGF-β were quantitatively determined by ELISA. Results: The levels of IL-17, IL-21, and IL-22 in sera were significantly higher (P

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Journal title

volume 15  issue 1

pages  59- 67

publication date 2018-03-01

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