Comparative Efficacy Study of N-Chromosome Royal Jelly Versus Semelil (ANGIPARS) on Wound Healing of Diabetic Rats

Authors

  • Azam Aliasghari Veshareh Department of Microbiology, Faculty of Biological Sciences, Alzahra University, Tehran, Iran.
  • Maryam Khezri Department of Chemistry, Faculty of Chemistry, University of Isfahan, Isfahan, Iran.
  • Mohammad Rabbani Khorasgani Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science & Technology, University of Isfahan, Isfahan, Iran.
  • Saeed Ahmadi Majd Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science & Technology, University of Isfahan, Isfahan, Iran.
  • Sayed Rasoul Zaker Department of Cell and Molecular Biology & Microbiology, Faculty of Biological Science & Technology, University of Isfahan, Isfahan, Iran.
Abstract:

Objective: The healing effects of two different dilutions (5 & 100%) of N-Chromosome Royal Jelly and ANGIPARS ointment were investigated and measured on experimental injuries in streptozotocin (STZ)-induced diabetic rats. This study investigated the healing effects of 2 different N Chromosome Royal Jelly dilutions on injuries of STZ-induced diabetic rats. Materials and Methods: For diabetes induction, male Wistar rats received STZ (55 mg/kg) intraperitoneally and plasma glucose level measurement after 72 hours demonstrated diabetes induction. Rats were randomly divided into 5 groups of 6 members and one square centimeter (cm2) wound was surgically induced in the dorsal region of each rat. The test groups were treated with ANGIPARS, undiluted royal jelly N chromosome, and royal jelly N chromosome 5% separately. The control groups were including non-diabetic and untreated diabetic rats. Results: The findings indicate a significant acceleration in wound healing of the diabetic rats treated by ANGIPARS ointment or royal jelly N chromosomes 5%. RJ also shortened the healing period of desquamated skin lesions. Thus, RJ possesses an anti-inflammatory action and is able to augment wound healing, but does not have an insulin-like action in streptozotocin-diabetic rats. Conclusion: Regarding the mentioned findings, royal jelly as a natural product may play an effective role in treating chronic wounds in mice, which makes it a proper candidate for use in human wound repair. Nonetheless, it seems that determination of the suitable dilution of this compound will result in better effects, thus more studies are recommended.

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Journal title

volume 14  issue 4

pages  223- 230

publication date 2022-11

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