Circulating Levels of Pro-inflammatory Cytokines in Patients with Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis

Authors

  • Abolghasem Hadinia Department of Genetic, Marvdasht branch, Islamic Azad University, Marvdasht, Iran
  • Amir Hossein Doustimotlagh Cellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, Iran|Department of Clinical Biochemistry, Faculty of Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
  • Arash Arya Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
  • Mojtaba Jafarinia Department of Genetic, Marvdasht branch, Islamic Azad University, Marvdasht, Iran
Abstract:

Background: Pro-inflammatory cytokines are associated with systemic inflammatory responses. Objective: To investigate the levels of pro-inflammatory cytokines (IL-1b, IL-6, and TNF-a) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals. Methods: This case-control study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy volunteers. The plasma level of IL-1b, IL-6, and TNF-a were determined by ELISA, and biochemical parameters were measured using colorimetric methods. Results: IL-1b and IL-6 levels were significantly higher in patients with NASH compared with NAFL and control group. However, TNF-a levels had no significant variations in NAFL and NASH patients compared to the control group (p=0.903 and p=0.960, respectively). Conclusion: Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH.

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Journal title

volume 16  issue 4

pages  327- 333

publication date 2019-12-30

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