Case Report: Combination Therapy with Mesenchymal Stem Cells and Granulocyte-Colony Stimulating Factor in a Case of Spinal Cord Injury

Authors

  • Amir Hassan Kohan Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Babak Arjmand Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Hamid Reza Aghayan Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Hooshang Saberi Brain and Spinal Cord Injury Research Center (BASIR), Imam Khomeini Hospital Complex, Keshavarz Blvd., Tehran, Iran.
  • Keyvan Tayebi Meybodi Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Mohammad Haghpanahi Department of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
  • Mohammad Taghvaei Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Nazi Derakhshanrad Brain and Spinal cord Injury Research Center, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  • Shahrokh Rahmani Department of Mechanical Engineering, Iran University of Science and Technology (IUST), Tehran, Iran
Abstract:

Introduction: Various neuroregenerative procedures have been recently employed along with neurorehabilitation programs to promote neurological function after Spinal Cord Injury (SCI), and recently most of them have focused on the acute stage of spinal cord injury. In this report, we present a case of acute SCI treated with neuroprotective treatments in conjunction with conventional rehabilitation program. Methods: A case of acute penetrative SCI (gunshot wound), 40 years old, was treated with intrathecal bone marrow derived stem cells and parenteral Granulocyte-Colony Stimulating Factor (G-CSF) along with rehabilitation program. The neurological outcomes as well as safety issues have been reported. Results: Assessment with American Spinal Injury Association (ASIA), showed neurological improvement, meanwhile he reported neuropathic pain, which was amenable to oral medication. Discussion: In the acute setting, combination therapy of G-CSF and intrathecal Mesenchymal Stem Cells (MSCs) was safe in our case as an adjunct to conventional rehabilitation programs. Further controlled studies are needed to find possible side effects, and establish net efficacy.

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Journal title

volume 6  issue 4

pages  299- 305

publication date 2015-10

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