Carvacrol attenuates serum levels of total protein, phospholipase A2 and histamine in asthmatic guinea pig

Authors

  • Mohammad Hossein Boskabady Neurogenic Inflammation Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mostafa Boskabady Neurogenic Inflammation Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Negin Yahyazadeh Neurogenic Inflammation Research Centre and Department of Physiology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Sedigheh Jalali Department of Biology, Payam Noor University, 19395-4697 Tehran, Iran
Abstract:

Objective: Pharmacological effects of carvacrol such as its anti-inflammatory activities have been shows. In this study the effects of carvacrol on serum levels of total protein (TP), phospholipase A2 (PLA2) and histamine in sensitized guinea pigs was evaluated. Materials and Methods: Sensitized guinea pigs were given drinking water alone (group S), drinking water containing three concentrations of carvacrol (40, 80 and 160 µg/ml) or dexamethasone. Serum levels of TP, PLA2 and histamine were examined I all sensitized groups as well as a non-sensitized control group (n=6 for each group). Results: In sensitized animals, serum levels of TP, PLA2 and histamine were significantly increased compared to control animals (p

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carvacrol attenuates serum levels of total protein, phospholipase a2 and histamine in asthmatic guinea pig

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Journal title

volume 6  issue 6

pages  636- 642

publication date 2016-11-01

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