BK Virus-Associated Hemorrhagic Cystitis in Children Suffering from Malignancies: Report of Three Cases

Authors

  • Neda Ashayeri Department of Hematology-Oncology, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, IR
  • Shahla Ansari Damavandi Department of Hematology-Oncology, Ali Asghar Children's Hospital, Iran University of Medical Sciences, Tehran, IR
Abstract:

BK virus-associated hemorrhagic cystitis (HC) is frequent in patients undergoing bone marrow transplantation, but it rarely occurs among other immunosuppressed patients particularly in those who are receiving chemotherapy for hematologic malignancies. Herein, we report three children with malignancies suffering from hemorrhagic cystitis due to BK virus infection who were successfully improved. Early detection of BK virus using RT-PCR technique was undertaken. With administration of antiviral agents; specifically, IVIG or leflunomide, BK virus-associated HC could be successfully managed in children affected by malignancies and consequently, chemotherapy of underlying disorder might be continued after virus elimination.

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Journal title

volume 11  issue 1

pages  33- 35

publication date 2019-03

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