Bivalent DNA Vaccination with Genes Encoding Leishmania major Cysteine Proteinases Type I and II Protects Mice Against Infectious Challenge
Authors: not saved
Abstract:
This article doesn't have abstract
similar resources
DNA vaccination with a plasmid encoding LACK-TSA fusion against Leishmania major infection in BALB/c mice.
Vaccination would be the most important strategy for the prevention and elimination of leishmaniasis. The aim of the present study was to compare the immune responses induced following DNA vaccination with LACK (Leishmania analogue of the receptor kinase C), TSA (Thiol-specific-antioxidant) genes alone or LACK-TSA fusion against cutaneous leishmaniasis (CL). Cellular and humoral immune response...
full textDNA immunization with the gene encoding P4 nuclease of Leishmania amazonensis protects mice against cutaneous Leishmaniasis.
Infection with the protozoan parasite Leishmania amazonensis can cause diverse clinical forms of leishmaniasis. Immunization with purified P4 nuclease protein has been shown to elicit a protective response in mice challenged with L. amazonensis and L. pifanoi. To explore the potential of a DNA-based vaccine, we tested the L. amazonensis gene encoding P4 nuclease as well as adjuvant constructs e...
full textProtective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum.
Leishmania infantum is known to be associated with visceral leishmaniasis in Iran and canids are natural reservoirs. Control of disease in dogs appears to be one of the most effective approaches for interrupting the domestic cycle of the disease. In search for successful vaccine strategies, we evaluated the cysteine proteinases (CPs) type I and II using a heterologous prime-boost regime for vac...
full textImmunization with Leishmania major exogenous antigens protects susceptible BALB/c mice against challenge infection with L. major.
The potential of Leishmania major culture-derived soluble exogenous antigens (SEAgs) to induce a protective response in susceptible BALB/c mice challenged with L. major promastigotes was investigated. Groups of BALB/c mice were immunized with L. major SEAgs alone, L. major SEAgs coadministered with either alum (aluminum hydroxide gel) or recombinant murine interleukin-12 (rmIL-12), L. major SEA...
full textimmunological responses of naturally infected dogs to type i and ii recombinant cysteine proteinases of leishmania infantum
purpose: evaluation of humoral and cellular immune responses of naturally infected dogs against type i (rcpb) (recombinant cycsteine proteinase b), and ii (rcpa) (recombinant cycsteine proteinase a) recombinant cysteine proteinases and c-terminal extension (cte) of leishmania infantum (l. infantum). materials and methods: in this study, fourteen infected dogs (7 with symptoms, 7 asymptomatics)...
full textDNA vaccination protects mice against challenge with Listeria monocytogenes expressing the hepatitis C virus NS3 protein.
The goal of this study was to develop a new surrogate challenge model for use in evaluating protective cell-mediated immune responses against hepatitis C virus (HCV) antigens. The use of recombinant Listeria monocytogenes organisms which express HCV antigens provides novel tools with which to assay such in vivo protection, as expression of immunity against this hepatotropic bacterial pathogen i...
full textMy Resources
Journal title
volume 2 issue 1
pages 35- 43
publication date 2004-01-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023