Biotransformation of Monoterpenoids by Suspension Cultures of Lavandula angustifolia

Authors

  • Abdolali Mohagheghzadeh Department of Pharmacognosy, Faculty of Pharmacy, and Pharmaceutical Research Center, Shiraz University of Medical Sciences, Shiraz, I. R. Iran
  • Azra Gholami Department of Pharmacognosy, Faculty of Pharmacy, and Pharmaceutical Research Center, Shiraz University of Medical Sciences, Shiraz, I. R. Iran
  • Keith J Harkissb School of Pharmacy, University of Bradford, Bradford, BD7 1DP, UK
  • Mahmood Mosaddegh Traditional Medicine and Materia Medica Research Center, Shaheed Beheshti University of Medical Sciences, Tehran, I. R. Iran
  • Peter A Linley School of Pharmacy, University of Bradford, Bradford, BD7 1DP, UK
Abstract:

     Callus and suspension cultures of Lavandula angustifolia Mill. (Lamiaceae) were established and the effect of different culture media on growth rate was investigated. Terpenoids added to suspension culture to investigate their biotrans-formation. All samples were analyzed by gas chromatography (GC) and GC-mass spectroscopy (MS). Octan-1-ol, citronellol, linalool, borneol and geraniol were biotransformed products of octanal, citronellal, linalyl acetate, bornyl acetate and geranyl acetate, respectively. Citronellol, linalool, borneol, and menthol didn't change by L. angustifolia suspension cultures. Blue pigment production by cultures of L. angustifolia was also studied. Ester hydrolysis and oxidation were the main reactions which occurred in biotransformation process, which may be attributed to the presence of related or bifunctional enzymes. This technique is a possible way of the production of expensive or rare compounds from cheap and plentiful substrates.

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Journal title

volume 3  issue 2

pages  93- 100

publication date 2007-04-01

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