Basil and Dracocephalum kotschyi alcoholic extracts affect BCL2 expression and HepG2 cell proliferation

Background: Liver cancer is the second outstanding reason for cancer-related death global and thus a main public health challenge. Plant-based drugs are regarded as promising therapies. Basil and Dracocephalum kotschyi extracts have shown therapeutic impacts on various cancers. Therefore, we assessed the effects of the extract of Basil and Dracocephalum kotschyi on cell proliferation and BCL2 expression in the HepG2 cell line. Materials and Methods: In this experimental study, the HepG2 cell line was selected for treatment with the alcoholic extract of Basil and Dracocephalum kotschyi extracts. Cell proliferation was examined in the presence of various concentrations of the Basil and Dracocephalum kotschyi extracts by MTT-assay. Moreover, the effect of the alcoholic extract of Basil and Dracocephalum kotschyi on BCL2 expression was evaluated using quantitative real-time polymerase chain reaction (qRT-PCR). Results: Cell proliferation studies represented anticancer characteristics of dose-dependent of the alcoholic extract of Basil and Dracocephalum kotschyi. Additionally, the extract of Basil and Dracocephalum kotschyi led to the decreased expression of BCL2 in HepG2 cell line. Conclusion: These findings propose Basil and Dracocephalum kotschyi as two promising candidates for future anticancer research. .