Association of Tumor Necrosis Factor-α (TNF-α) -308G>A and -238G>A Polymorphisms with Recurrent Pregnancy Loss Risk: A Meta-Analysis

Authors

  • Fereshteh Aslebahar Department of Obstetrics and Gynecology, Semnan University of Medical Sciences, Semnan, Iran
  • Hossein Neamatzadeh 3Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mahmood Noori-Shadkam Mother and Newborn Health Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mahta Mazaheri Department of Medical Genetics, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
  • Mojgan Karimi-Zarchi Department of Obstetrics and Gynecology, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract:

Background: Studies have been carried out to evaluate the association of tumor necrosis factor-α (TNF-α) gene promoter region polymorphisms with recurrent pregnancy loss (RPL) risk. However, the results remain controversial and incomplete. Hence, we performed a meta-analysis to evaluate the association of TNF-α -308G>A and -238G>A polymorphisms with RPL risk. Materials and Methods: A comprehensive search of PubMed, Web of Knowledge and EMBASE was performed to identify relevant studies up to December 1, 2017. The associations was assessed by odds ratios (OR) and the corresponding 95% confidence interval (CI). Results: A total of 29 case-control studies, including 20 studies on TNF-α -308G>A (3,461 cases and 3,895 controls) and nine studies on TNF-α -238G>A (2,589 cases and 2,664 controls), were included in the meta-analysis. Overall, we found TNF-α -308G>A polymorphism can increase RPL risk under the homozygote (OR = 1.716, 95% CI 1.210-2.433, p= 0.002) and the recessive model (OR = 1.554, 95% CI 1.100-2.196, p= 0.012). The results showed that TNF-α -238 G>A polymorphism was significantly associated with increased risk of RPL under the allele model (OR = 1.554, 95% CI 1.100-2.196, p= 0.012). Stratified analysis revealed that there was a significant association between the TNF-α -308G>A polymorphism and increased RPL risk in Asians under the homozygote (OR=2.190, 95% CI 1.465-3.274, p≤0.001), the dominant (OR = 1.642, 95% CI 1.269-2.125, p≤0.001) and the recessive (OR=1.456, 95% CI 1.039-2.040, p=0.029) models, but not in Caucasians. A non-significant association between TNF-α -238G>A and RPL risk was identified by ethnicity. Moreover, TNF-α -308G>A and -238G>A polymorphisms were significantly associated with increased risk of RPL in high quality studies and RFLP-PCR subgroups. Conclusion: The present meta-analysis demonstrates that TNF-α -308G>A and -238G>A polymorphisms are associated with risk of RPL.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

tumor necrosis factor-α-308 g/a polymorphisms and risk of hepatocellular carcinoma: a meta-analysis

conclusions this meta-analysis indicated that the tnf-α-308 g/a polymorphism is significantly associated with increased susceptibility to hcc. however, to confirm this finding, more studies are needed on tnf-α-308 g/a polymorphisms associated with hcc. context hepatocellular carcinoma (hcc) is a common disorder throughout the world that can develop due to various factors, including genetics. tu...

full text

Association of TNF-α genetic polymorphisms with recurrent pregnancy loss risk: a systematic review and meta-analysis

BACKGROUND Several studies on the association of tumor necrosis factor alpha (TNF-α) polymorphisms with recurrent pregnancy loss (RPL) risk have reported conflicting results. The present meta-analysis was conducted to provide a more precise estimation of these relationships and to investigate the real association between TNF-α polymorphisms and RPL. METHODS An extensive eligible literature se...

full text

Association between Tumor Necrosis Factor- α-308 G/A Polymorphism and Multiple Sclerosis: A Systematic Review and Meta-Analysis

Multiple sclerosis (MS) is a complex polygenic disease in which gene-environment interactions are important. A number of studies have investigated the association between tumor necrosis factor-α (TNF-α) -308 G/A polymorphism (substitution G→A, designated as TNF1 and TNF2) and MS susceptibility in different populations, but the results of individual studies have been inconsistent. Therefore, per...

full text

The effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk

This meta-analysis of 23 eligible articles comprehensively and quantitatively evaluated the effects of tumor necrosis factor-α (TNF-α) rs1800629 and rs361525 polymorphisms on sepsis risk. We found that TNF-α rs1800629 was associated with increased sepsis risk in the overall population in four genetic models, including A vs. G (P<0.001, odds ratio (OR)=1.32), GA vs. GG (P<0.001, OR=1.46), GA+AA ...

full text

Tumor Necrosis Factor-α-308 G/A Polymorphisms and Risk of Hepatocellular Carcinoma: A Meta-Analysis

CONTEXT Hepatocellular carcinoma (HCC) is a common disorder throughout the world that can develop due to various factors, including genetics. Tumor necrosis factor-α (TNF-α) is the most frequently studied cytokine related to the risk of developing HCC, and an association between the 308 position of the TNF-α promoter (TNF-α-308) and HCC risk has been confirmed in various reports. EVIDENCE ACQ...

full text

Associations between Tumor Necrosis Factor-α Polymorphisms and Risk of Psoriasis: A Meta-Analysis

BACKGROUND Tumor necrosis factor-α (TNF-α) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-α polymorphisms and psoriasis risk. METHODS We performed a meta-analysis to evaluate the associations between TNF-α polymorphisms and psoriasis. Electronic searches of Pubmed, Embase, and Web of Scien...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 12  issue 4

pages  284- 292

publication date 2019-10-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023