Association of IL18 gene polymorphisms (positions -656 G/T, -137 G/C and +105A/C) with Kala-Azar
Authors
Abstract:
Background & Objective: Host resistance to Leishmania infection is mediated by cellular immune responses leading to macrophage activation and parasite killing. IL-18 known as interferon-γ inducing factor, stimulate IFN-γ production by T-cells. According to the important role of IL-18 in defense against VL and known effect of IL-18 gene polymorphisms on its production, the aim of this study was to investigate the probable relation between IL-18 gene polymorphisms and susceptibility to VL in Iranian patients. Materials & Methods: The study groups included 118 pediatric patients suffered from VL and 156 non-relative healthy persons from the same endemic area as the patients. In both study groups IL-18 gene polymorphisms at positions -656 G/T, -137 G/C and +105A/C (codon 35/3) were analyzed by PCR-RFLP (Polymerase Chain Reaction - Restriction Fregment Length Polymorphism). Results: The result showed that the frequency of T allele at position -656 was significantly higher in the controls compared to that in the patients (P=0.047). But in none of the genotypes of IL-18 there was significant difference between patients and controls. In addition, the distribution of ATG haplotype and AGG/ATG haplo-genotype were significantly higher in the controls compared to that in patients with VL (P=0.043and P=0.044, respectively). Furthermore a strong LDs (P<0.001) were detected between the -607, -137 and codon 35/3 SNPs. Conclusion: In conclusion, this study showed that the frequency of T allele at position -656 and ATG haplotype and AGG/ATG haplogenotype (positions +105, -656 and -137) were significantly higher in the controls. To the best of our knowledge no study has been conducted on IL-18 gene polymorphisms and VL in other countries, therefore, we were not able to compare our results with other investigations, so it seems that more researches in this field on other populations will be worthy.
similar resources
Kala-azar and Post–Kala-azar Dermal Leishmaniasis, Assam, India
remain unknown. S. delphini has rarely been identified in horses, but, as we observed, it may be misidentified by conventional methods. Although colonization or contamination appeared most likely in the instances we describe, these findings suggest that this opportunistic pathogen can be found in horses and might be pathogenic in certain situations. Our findings highlight the importance of usin...
full textKala Azar
To the Editor, "Indian Medical Gazette." Sir,?In the communication from Surgn.-Capt. P. W. O'Gorman in your issue for November regarding hda azar I see no mention of the fact of his having made use of the microscope in his search for anchylostomata. If, instead of straining the motion and examining them microscopically, he examines them microscopically according to the directions given by Sonsi...
full textKala-Azar
The incidence of infantile visceral leishmaniasis is currently increasing, at least in the Mediterranean region. Most cases seen in France occur on the Mediterranean coast or are imported from Africa. However, contamination in other regions of France is not an exceptional occurrence and may raise diagnostic problems. The parasite reservoir is the dog population in which the prevalence of Leishm...
full textKala-Azar
had several private cases sent to us by private practitioners of the city. Almost all those cases were in the initial stages. The peripheral blood of these patients was examined every week (each time about ̂ dozen slides), but I rarely found the parasites in the early stages. Still, other changes in the blood and the characteristic temperature of the disease made us suspect a case to be one of K...
full textthe study of aaag repeat polymorphism in promoter of errg gene and its association with the risk of breast cancer in isfahan region
چکیده: سرطان پستان دومین عامل مرگ مرتبط با سرطان در خانم ها است. از آنجا که سرطان پستان یک تومور وابسته به هورمون است، می تواند توسط وضعیت هورمون های استروئیدی شامل استروژن و پروژسترون تنظیم شود. استروژن نقش مهمی در توسعه و پیشرفت سرطان پستان ایفا می کند و تاثیر خود را روی بیان ژن های هدف از طریق گیرنده های استروژن اعمال می کند. اما گروه دیگری از گیرنده های هسته ای به نام گیرنده های مرتبط به ا...
15 صفحه اولMy Resources
Journal title
volume 2 issue 2
pages 59- 65
publication date 2012-09
By following a journal you will be notified via email when a new issue of this journal is published.
No Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023