Assessing clinical laboratory funding of Sickle Cell Disease and others associated Disorders in Khuzestan Province

Objective:  The aim of this study was to assess clinical laboratory funding for differential diagnosis of sickle cell disease (SCD) and other associated disorders for better understanding of clinical types and prevention of sickling events. Material and Methods:  This is a descriptive crossed-sectional study that analyzed the peripheral blood film, sickle cell preparation, hemoglobin electrophoresis, CBC, RBC indices serum ferritin related to clinical features on  referral cases and their family from different parts of Khuzestan province. Twenty-eight cases (SS) and others associated disorders, 16 (SIDA), sickle – thalassemia, 32 (Sβ +), 30 cases of (Sβ °) and 31(AS), were studied from 1999 to 2002. Results: Family reviewed showed 97% of sickle carrier states were among the ethnics Arabian origin, 10% Arab – Persian half breeds only 3% from old Persia in origin. Elevated HbF was seen in most of the patients who were prominent in SS rather than other associated heterozygote and sickle traits. About 85% of patient had HbF level more than 13%.  MCV>80 MCH>27 were obtained in SS and sickle traits. Baseline WBC counts (neutrophils  polymorphoneuclear) in SS individuals are elevated. Conclusions:  General appearance of these patients usually good looking Caucasian boys and girls with a diagnosis of SCD others associated disorders.