Apoptotic and proliferative activity of mouse gastric mucosa following oral administration of fumonisin B1

Authors

  • Abbas Tavassoli Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
  • Ali Mohammad Alizadeh 1 Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran 2 Cancer Model Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Alireza Khosravi Medical Parasitology and Mycology Department, School of Medicine, Tehran University, Tehran, Iran
  • Fahimeh Mohammadghasemi Cellular and Molecular Research Center, Faculty of Medicine, Guilan University of Medical Sciences, Rasht, Iran
  • Fatemeh Amini najafi Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
  • Kazem Zendehdel Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
  • Zahra Kamyabi-moghaddam Department of Pathology, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran
Abstract:

Objective(s):Fumonisins are a group of toxic and carcinogenic mycotoxins, which contaminate the grains and their products. The aim of this study was to examine the apoptotic and proliferative activity of mouse gastric mucosa following administration of fumonisin B1 (FB1).    Materials and Methods: Twenty-nine female mice divided into treatment (n=15) and control (n=14) groups. The treatment group received FB1 (150 mg/kg diet) for 16 weeks. The gastric atrophy was allocated using grading criteria modeled on the updated Sydney System. Immunohistochemistry studies were performed for evaluation of apoptosis and proliferative activity in gastric mucosa. Results: Mild to moderate gastric atrophy were observed in microscopic findings of the gastric mucosa in treated animals (P

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Journal title

volume 18  issue 1

pages  8- 13

publication date 2015-01-01

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