Antioxidant, anti-acetylcholinesterase, anti-inflammatory and DNA protection activities of Glaucium grandiflorum var. grandiflorum.

Authors

  • Aynur Sarı Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
  • Hasan Şahin Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
  • Nurten Özsoy Department of Biochemistry, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey
  • Pınar Aksoy-Sagirli Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, 34116 Istanbul, Turkey.
Abstract:

In this study, the antioxidant, antiacetylcholinesterase, anti-inflammatory, and DNA protecting activities of the aerial parts of Glaucium grandiflorum var. grandiflorum were evaluated. It was found that the lyophilized methanolic extract exhibited an inhibitory capacity against FeCl3/ascorbic acid induced posphatidylcholine liposome oxidation (EC50 = 2.62  0.08 mg/mL), quenched HOCl (5.87  0.07 mg/mL ), stable DPPH (EC50 = 2.03  0.17 mg/mL) and ABTS cation radicals (EC50 = 4.80  0.14 mg/mL) and acted as reductant as expressed by the FRAP value (2.453  0.07 mM/L Fe2+). The acethylcholinesterase inhibition capacity of the lyophilized methanolic extract at 320 μg/mL (80.75  1.59%) was found to be strong and almost equal to the inhibition capacity of the positive control, galantamine (82.23  2.21%) at 25 μg/mL. The significant AChE inhibitory activity suggests that the extract may be beneficial in the treatment of Alzheimer’s disease. The extract also showed inhibitory activity against plasmid DNA damage (94 %), as well as COX-2 (69.05 %), which is a target for many anti-inflammatory and cancer-preventive drugs. These results indicate that G. grandiflorum var. grandiflorum methanolic extract is an excellent source of compounds with antioxidant, anti-cholinesterase and anti-inflammatory properties that prevent DNA damage.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Anti-Inflammatory, Antioxidant, Anti-Angiogenic and Skin Whitening Activities of Phryma leptostachya var. asiatica Hara Extract

This work aimed to assess some pharmacological activities of P. leptostachya var. asiatica Hara. The dried roots of P. leptostachya var. asiatica Hara were extracted with 70% ethanol to generate the powdered extract, named PLE. Anti-angiogenic activity was detected using chick chorioallantoic membrane (CAM) assay. In vitro anti-inflammatory activity was evaluated via analyzing nitric oxide (NO)...

full text

Antioxidant and Anti-Inflammatory Activities of Barettin

In this paper, we present novel bioactivity for barettin isolated from the marine sponge Geodia barretti. We found that barettin showed strong antioxidant activity in biochemical assays as well as in a lipid peroxidation cell assay. A de-brominated synthetic analogue of barettin did not show the same activity in the antioxidant cell assay, indicating that bromine is important for cellular activ...

full text

Anthocyanins: Antioxidant and/or anti-inflammatory activities

Anthocyanins are polyphenols with known antioxidant activity which may be responsible for some biological activities including the prevention or lowering the risk of cardiovascular disease, diabetes, arthritis and cancer. Nevertheless such properties, their stability and bioavailability depend on their chemical structure. In the present work a brief review is made on chemical structures, bioava...

full text

Anti-HIV-1 Activities of the Extracts from the Medicinal Plant Linum grandiflorum Desf

As part of our screening of anti-AIDS agents from natural sources e.g. Ixora undulata, Paulownia tomentosa, Fortunella margarita, Aegle marmelos and Erythrina abyssinica, the different organic and aqueous extracts of Linum grandiflorum leaves and seeds were evaluated in vitro by the microculture tetrazolium (MTT) assay. The activity of the tested extracts against multiplication of HIV-1 wild ty...

full text

Chemical Composition and Biological Activities of Allium roseum L. var. grandiflorum Briq. Essential Oil.

Allium roseum L. (Alliaceae) endemic mediterranean specie was represented in the North Africa by 12 different taxa. In the present study, chemical composition, antiproliferative, antioxidant and antimicrobial activities of the essential oil extracted from A. roseum var. grandiflorum Briq. bulbs collected in the North of Tunisia were investigated. Chemical characterization has shown methyl metha...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 17  issue 2

pages  677- 684

publication date 2018-04-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023