Antinociceptive Effect of Promethazine in Mice
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Abstract:
Objective(s) The present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. Materials and Methods Antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. Results Promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant inhibition of the second phase response in the formalin pain model (P
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Journal title
volume 12 issue 3
pages 140- 145
publication date 2009-07-01
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