ANTINEUTROPHIL CY TOPLASMIC AUTOANTIBODIES IN SYSTEMIC LUPUS ERYTHEMATOSUS
Authors
Abstract:
Antineutrophil cytoplasmic autoantibodies (ANCA) were first described in patients with necrotizing glomerulonephritis. The original observation passed unnoticed until an association was made between ANCA and active Wegener's granulomatosis. Since then, tremendous progress has been made in elucidating the association between ANCA subtypes and clinicopathologic syndromes, and the potential pathologic role of ANCA in vascular inflammation. The gold standard method for ANCA detection is indirect immunofluorescence (IIF) microscopy of ethanol-fixed cells. By this technique two general patterns of ANCA, acytoplasmic pattern (c-ANCA) and a perinuclear pattern (P-ANCA) can be identifed. Recently some reports have been published concerning the prevalence, subtypes, role and specificity of ANCA.ln this study we searched for ANCA prevalence, subtypes, and its relationship with disease activity in SLE patients by IIF technique. Our results showed that all normal subjects were ANCA negative, while at least 50% of patients were ANCA positive (majority c-ANCA type). Statistical analysis revealed that there is no correlation between the presence of ANCA and disease activity (p<0.01).
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Journal title
volume 11 issue 1
pages 15- 17
publication date 1997-05
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