Antifungal drug resistance of yeasts in dermatology: mechanisms, epidemiology and clinical impact

Authors

  • Fattahi, Azam Center for Research and Training in Skin Diseases and Leprosy,Tehran University of Medical Sciences, Tehran, Iran
  • Ghasemi, Reza Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Iranpanah, Sayna Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Lotfali, Ensieh Department of Medical Parasitology and Mycology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Rezaee, Yasaman Student Research Committee, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:

Superficial dermatophytoses are among the most common infectious disease. The most commonly used antifungal categories reazoles, polyenes and echinocandins. Due to the limited number of available antifungal drugs, toxicity and the emergence of resistant (intrinsic or acquired) strains, antifungal strategy needs to be developed. Recently the researchers try to find alternative antifungal agents. This review emphasizes the action and resistance mechanisms to antifungal drugs, the search for new agents, drug- resistant genes, and the application of combination therapy and immunomodulators (using cytokines and gamma interferon which can provide novel insights to fighting fungal infections). A comprehensive review study was performed using the keywords including Candida, antifungal drugs and drug resistance in valid medical databases, mainly PubMed. Articles that were most relevant to the purposes of the study were selected and studied. Problems with antifungal resistance and the emergence of resistant strains of fungal has produced an enormous demand for new antifungal agents. The clinical complexity of patients with resistant mycoses prevents an easy approach to the detection, prevention, and management of antifungal drug resistance. Continuing investigation will illustrate the role of susceptibility testing for resistant mycoses and on clinical strategies used to fighting antifungal drug resistance in pathogenic fungi.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Azole Antifungal Drug Cross-Resistance: Mechanisms, Epidemiology, and Clinical Significance

full text

Mechanisms of resistance to antifungal agents: yeasts and filamentous fungi.

Failure to respond to antifungal therapy could be due to in vitro resistance (intrinsic or developed during therapy) or clinical resistance; the latter is associated with numerous factors related to the host, the antifungal agent, or the infecting isolate. Recently, a susceptible MIC breakpoint ( < or =2 microg/ml) was designed for Candida spp. to all three available echinocandins, anidulafungi...

full text

Acquired antifungal drug resistance in Aspergillus fumigatus: epidemiology and detection.

Voriconazole is the recommended agent for invasive aspergillosis, with lipid amphotericin B or caspofungin as second line treatment choices. Being the only agents available in oral formulation, azoles are used in chronic infections and often over longer time periods. In addition to being used in clinical medicine, azoles are employed extensively in agriculture. Azole-resistant Aspergillus has b...

full text

Mechanisms of antifungal resistance

The many drugs that are available at present to treat fungal infections can be divided into four broad groups on the basis of their mechanism of action. These antifungal agents either inhibit macromolecule synthesis (flucytosine), impair membrane barrier function (polyenes), inhibit ergosterol synthesis (allylamines, thiocarbamates, azole derivatives, morpholines), or interact with microtubules...

full text

Epidemiology and antifungal resistance in invasive candidiasis

The epidemiology of Candida infections has changed over the last two decades: The number of patients suffering from such infections has increased dramatically and the Candida species involved have become more numerous as Candida albicans is replaced as an infecting agent by various non-C. albicans species (NAC). At the same time, additional antifungal agents have become available. The different...

full text

The potential impact of antifungal drug resistance mechanisms on the host immune response to Candida

A large number of studies have been published over the last two decades examining molecular mechanisms of antifungal resistance in Candida species. However, few of these studies have explored how such mechanisms influence the host immune response to this opportunistic pathogen. With recent advances in our understanding of host immunity to Candida, a body of emerging literature has begun to expl...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 11  issue 1

pages  44- 61

publication date 2020-04

{@ msg @}

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023