Anti-inflammatory and antimicrobial studies of biosensitive Knoevenagel condensate β-ketoanilide Schiff base and its Co(II), Ni(II), Cu(II) and Zn(II) complexes

A new series of transition metal complexes of Co(II), Ni(II), Cu(II) and Zn(II), has beensynthesized from the Knoevenagel condensate Schiff base ligand(L) derived from β-ketoanilideand furfural with o-phenylenediamine and diethylmalonate. Structural features were determinedby spectral and analytical techniques. Square-planar geometry has been adopted by thecomplexes except cobalt complex which has an octahedral geometry. The synthesized ligand andits complexes were screened for their anti-inflammatory activity in male albino rats(Carrageenan-induced rat paw oedema model). Among these complexes, copper complex showssignificant anti-inflammatory activity. It exhibits significant dose dependent activity in acuteinflammation. The doses of 100 and 200 mg kg-1 bw produced 38.3 % and 42.8 % inhibitionrespectively after 3 h as compared with that of the standard drug (indomethacin) which showed48.5 % inhibition. The in vitro antimicrobial activity of the ligand and its complexes wasmonitored by disc diffusion method. It has been found that complexes have higher antimicrobialactivity than that of free ligand.