Anti-inflammatory activity and chemical composition of Pycnocycla bashagardiana fruit’s essential oil in animal models

Authors

  • Fatemeh Jahandar Herbal Medicines Research Center, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  • Jinous Asgarpanah Department of Pharmacognosy, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  • Parvaneh Najafizadeh Department of Pharmacology, Iran University of Medical Sciences, Tehran, Iran|Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
  • Zahra Mousavi Department of Pharmacology and Toxicology, Faculty of Pharmacy, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
Abstract:

Objective(s): Pycnocycla bashagardiana is an endemic species found only in Iran. Due to the presence of myristicin as the major component of the fruit’s oil we were prompted to assess the antinociceptive and anti-inflammatory properties of P. bashagardiana fruit’s essential oil (PBFEO). Materials and Methods: The analgesic activities of PBFEO (100, 200, and 400 mg/kg, IP) were studied by hot-plate and formalin tests in mice. Control and standard groups received vehicle and morphine (5 mg/kg, IP), respectively. The acute anti-inflammatory effect of PBFEO (200 and 400 mg/kg, IP) were assessed by carrageenan-induced paw edema method in 30 min, 1, 2, 3, and 4 hr after carrageenan injection and the chronic anti-inflammatory effect of PBFEO (50 and 100 mg/kg, IP) were assessed by the cotton pellet-induced granuloma method in rats. Results: In hot-plate and formalin tests, the studied doses of PBFEO were not effective. However, in carrageenan test, all studied doses ofPBFEO significantly reduced the paw edema in comparison to the control animals (P

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Journal title

volume 21  issue 2

pages  188- 193

publication date 2018-02-01

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