Anti-coagulation therapy following coronary endarterectomy in patient with coronary artery bypass graft

Authors

  • Ghassem Faghanzadeh Ganji Department of Cardiac Surgery , Ayatollah Rohani Hospital, Babol University of Medical Sciences, Babol , Iran
  • Hamid Reza Vafaey Department of Cardiac Surgery, Ayatollah Rouhani Hospital, Babol University of Medical Sciences, Babol, Iran.
  • Nadia Banihashem Department of Anesthesiology, Babol University of Medical Sciences, Babol, Iran
  • Sadaf Abbaspour Student Research Committee, Babol University of Medical Sciences, Babol, Iran
Abstract:

Background: Since there is a lack of research on postoperative anticoagulation protocol in patients undergoing coronary artery bypass graft (CABG) / coronary endarterectomy (CE), we recommend a new protocol for anticoagulation in these patients. Methods: In this double-blind randomized clinical trial study, 52 patients undergoing CABG / CE entered the study and were divided into two groups. In group 1, the patients were given&nbsp; warfarin(international normalized ratio (INR) between 2-3) together with 80 mg aspirin daily for 3 months. In group 2, the patients were given 75 mg plavix daily together with 80 mg aspirin daily for 3 months. We evaluated patients with electrocardiography, echocardiography and checking ceratin phosphokinase MB and troponin I in the several stages. The data were analysed SPSS Version18 software. Results: There was no significant difference between pre and post-operative Ejection fraction in patients with plavix (P=0.21) and warfarin (P=0.316) regimen. However, wall mrotion score was significantly better in clopidogrel &ndash; aspirin patients in late (3 months) post operation (p<0.001). Conclusions: Since warfarin has serious hemorrhagic complications and requires closed monitoring of serum drug activity by serial INR checking, it is recommended that clopidogrel &ndash; aspirin can be the preferred alternative anticoagulation therapy in CABG / CE patients.

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Journal title

volume 9  issue None

pages  27- 31

publication date 2018-01

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