An Efficient Protocol for the Synthesis of Carboacyclic Nucleosides via Aza-Conjugate Addition Reaction

Authors

  • Abdolkarim Zare Department of Chemistry, Payame Noor University (PNU), Tehran, I.R. IRAN
  • Ahmad Reza Moosavi-Zare Faculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRAN
  • Ali Reza Hasanijejad Department of Chemistry, Faculty of Sciences, Persian Gulf University, Bushehr, I.R. IRAN
  • Ardeshir Khazaei Faculty of Chemistry, Bu-Ali Sina University, Hamedan, I.R. IRAN
Abstract:

A new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to a,β-unsaturated esters in the presence of catalytic amount of LiOH.H2O (1.2-4.8 mol%) under microwave irradiation is described. This method affords the title compounds in good to excellent yields and in short reaction times.

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an efficient protocol for the synthesis of carboacyclic nucleosides via aza-conjugate addition reaction

a new efficient method for the synthesis of carboacyclic nucleosides as biologically interesting compounds via aza-conjugate addition of pyrimidine nucleobases to a,β-unsaturated esters in the presence of catalytic amount of lioh.h2o (1.2-4.8 mol%) under microwave irradiation is described. this method affords the title compounds in good to excellent yields and in short reaction times.

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Journal title

volume 29  issue 4

pages  67- 73

publication date 2010-12-01

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