Ameliorative property of the ethanolic extract of Tragopogon graminifolius DC. on carbon tetrachloride-induced hepatotoxicity in mice: A pharmacological examination

Authors

  • AKRAM ZANGENEH Department of Clinical Science, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran.
  • FARIBA HOSSEINI Biotechnology and Medicinal Plants Research Center, Ilam University of Medical Sciences, Ilam, Iran.
  • MOHAMMAD KAZEM KOOHI Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
  • SAMANEH GOORANI Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Abstract:

ABSTRACT Hepatotoxicity is the most common disorder with severe effects on quality of life. Tragopogon graminifolius DC. has been used in Iran as an astringent and bleeding inhibitor, wound healer and gastro-protector agent. To our knowledge, there are little evidence at hand on hepatoprotective activity of T. graminifolius. The present study was carried out to assess hepatoprotective property of T. graminifolius ethanolic extract on carbon tetrachloride (CCl4) induced hepatotoxicity in mice for 45 consecutive days. Fifty male mice were divided into five groups (n=10). Group 1 (control) received 1 ml/kg olive oil intraperitoneally (i.p.) and distilled water orally; Group 2 (untreated) received CCl4 (50% in olive oil, 1 ml/kg; i.p.); Groups 3, 4 and 5 received CCl4 and 30, 90 and 270 mg/kg of T. graminifolius (T30, T90 and T270), respectively. At 45th day, the mice were killed, dissected, then blood and liver samples were collected for biochemical and stereological parameters analysis. Biochemically, T. graminifolius at all doses (especially T270) could significantly (p≤0.05) reduce the raised levels of cholesterol, low density lipoprotein (LDL), triglyceride, alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transferase (GGT), total and conjugated bilirubin, and increase the decreased levels of high density lipoprotein (HDL), total protein, albumin, superoxide dismutase (SOD) and catalase (CAT). Stereologically, different doses of T. graminifolius (especially T270) decreased the weight and volume of the hepatic structures as compared to the untreated group significantly (p≤0.05). The obtained results indicate that T. graminifolius ethanolic extract, potential applications as a therapeutical supplement or medicine, after confirming clinical trial studies.  

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Assessment of the Hepatoprotective Activity of Tragopogon graminifolius DC. Aqueous Extract on CCl4- Induced Hepatotoxicity in Mice

Background and objectives: Tragopogon graminifolius DC. is widely used in Iranian traditional medicine as a gastro-protective and wound healer agent.  In the present study the hepatoprotective property of T. graminifolius DC. aqueous extract (TGAE) was investigated against carbon tetrachloride (CCl4) induced hepatocellular injury in mice. Me...

full text

the effect of aqueous extract of garlic on formalin-induced pain in male rats

چکیده اثر عصاره آبی سیر بر درد ناشی از آزمون فرمالین در موش صحرایی نر به کوشش نرگس اسکندری روزبهانی زمینه و هدف: گیاه سیر از خانواده لیلیاسه و گونهallium sativum بومی آسیای میانه بوده و از دوران ،باستان تاکنون به خواص درمانی متفاوت آن مثل: کاهندگی قندخون، کلسترول خون، فشار خون، اثرات مفیدآن بر دستگاه قلبی عروقی و بیماریهای انعقادی خون، اثرات آنتی اکسیداتیو، درمان بیماریهای تنفسی وگوارشی، ا...

15 صفحه اول

Hepatoprotective Activity of the Ethanolic Extract of Ficus carica Linn. Leaves in Carbon Tetrachloride- Induced Hepatotoxicity in Rats

The ethanolic extract of Ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic Albino rats induced via carbon tetrachloride. The degree of protection was measured by estimating biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), total protein (TP), total albumin (TA), alkaline phos...

full text

Hepatoprotective Activity of the Ethanolic Extract of Ficus carica Linn. Leaves in Carbon Tetrachloride- Induced Hepatotoxicity in Rats

The ethanolic extract of Ficus carica leaves was screened for hepatoprotective and antioxidant activity in hepatotoxic Albino rats induced via carbon tetrachloride. The degree of protection was measured by estimating biochemical parameters such as serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), total protein (TP), total albumin (TA), alkaline phos...

full text

Effect of propolis extract on acute carbon tetrachloride induced hepatotoxicity.

Ethanolic extract of propolis was administered to rats intoxicated by carbon tetrachloride. Administration of bolus dose of CCl4 (1.5 ml/kg, ip) resulted in elevation of serum transaminases and serum alkaline phosphatase activities. Levels of hepatic lipid peroxidation were significantly increased. On the contrary, there was significant decrease in hepatic reduced glutathione level. The propoli...

full text

Effects of Pistacia Vera Hydro-Alcoholic Extract on Carbon Tetrachloride-Induced Hepatotoxicity in Male Rats

Oxidizing agents play a major role in the pathogenesis of liver diseases. Pistacia vera (P. vera), contains many antioxidant substances including coenzyme 10, vitamin E and beta-carotene. The current study was designed to evaluate the probable effects of P. vera on carbon tetrachloride (CCl4)-induced hepatotoxicity in male rats. Frothy male Wistar rats were randomly divided into five groups inc...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 16  issue 1

pages  1- 8

publication date 2018-06

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023