ACE I/D and MMP-7 A-181G variants and the risk of end stage renal disease

Authors

  • Asad Vaisi-Raygani Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Hamed Abdi Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Hamid Nomani Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Maryam Tanhapoor Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Ziba Rahimi Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran
  • Zohreh Rahimi Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran| Department of Clinical Biochemistry, Medical School, Kermanshah University of Medical Sciences, Kermanshah, Iran
Abstract:

The variants of angiotensin converting enzyme (ACE) and matrix metalloproteinases (MMPs) genes might be involved in the pathogenesis of end stage renal disease (ESRD) and hypertension. We studied the ACE insertion/deletion (I/D) and MMP-7 A-181G variants in 99 unrelated ESRD patients and 117 individuals without renal complications from Western Iran with Kurdish ethnic background. The frequency of ACE I/D variants was not significantly different between ESRD patients and controls. However, the presence of ACE D allele increased the risk of hypertension in ESRD patients by 2.14-fold (P=0.036). The MMP-7 -181 AG genotype increased the risk of ESRD by 2.04 times (P=0.026). The present study indicated the absence of an association between the ACE I/D polymorphism with the risk of ESRD. However, the ACE D allele increased the risk of hypertension in ESRD patients. Also, the present study suggests a role for MMP-7 AG genotype in the pathogenesis of ESRD.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

ace i/d and mmp-7 a-181g variants and the risk of end stage renal disease

the variants of angiotensin converting enzyme (ace) and matrix metalloproteinases (mmps) genes might be involved in the pathogenesis of end stage renal disease (esrd) and hypertension. we studied the ace insertion/deletion (i/d) and mmp-7 a-181g variants in 99 unrelated esrd patients and 117 individuals without renal complications from western iran with kurdish ethnic background. the frequency ...

full text

ACE I/D and MMP-7 A-181G variants and the risk of end stage renal disease

The variants of angiotensin converting enzyme (ACE) and matrix metalloproteinases (MMPs) genes might be involved in the pathogenesis of end stage renal disease (ESRD) and hypertension. We studied the ACE insertion/deletion (I/D) and MMP-7 A-181G variants in 99 unrelated ESRD patients and 117 individuals without renal complications from Western Iran with Kurdish ethnic background. The frequency ...

full text

the study of practical and theoretical foundation of credit risk and its coverage

پس از بررسی هر کدام از فاکتورهای نوع صنعت, نوع ضمانت نامه, نرخ بهره , نرخ تورم, ریسک اعتباری کشورها, کارمزد, ریکاوری, gdp, پوشش و وثیقه بر ریسک اعتباری صندوق ضمانت صادرات ایران مشخص گردید که همه فاکتورها به استثنای ریسک اعتباری کشورها و کارمزد بقیه فاکتورها رابطه معناداری با ریسک اعتباری دارند در ضمن نرخ بهره , نرخ تورم, ریکاوری, و نوع صنعت و ریسک کشورها اثر عکس روی ریسک اعتباری داردو پوشش, وثی...

15 صفحه اول

legal aspects of end of life and end stage disease

Abstract:  Aims: End of Life (EOL) care providers potentially face by variety of legal and professional dilemma. This study is designed to review and analyze these challenges and approaches to solve them. Materials & Methods:   In this narrative review study, legal aspects of end-of-life care in subjects such as medical assisted dying, decision-making capacity and withdrawal of life-sustaining...

full text

The relationship between Aldosterone level and various LV conditions in patients with End-stage renal disease

Background: Aldosterone has been assumed to be implicated in left ventricular hypertrophy (LVH). Preventing the progression of LVH in the early period of end-stage renal disease (ESRD) can increase patient survival. In this study, therefore, we analyzed the relationship between aldosterone level and LVH in ESRD patients who underwent hemodialysis at Fatemeh Zahra Hospital and Imam Khomeini Hosp...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 6  issue 1

pages  41- 44

publication date 2017-03-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023