A Quick update from the Past to Current Status of Human Pluripotent Stem Cell-derived Hepatocyte culture systems

Authors

  • Vosough, Massoud Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
  • Zahmatkesh, Ensieh Department of Stem Cells and Developmental Biology, Cell Science Research Center, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran
Abstract:

Pluripotent stem cells (PSCs) may be offered as an unlimited cell source for the hepatocyte generation. The generation of hepatocytes from stem cells in vitro would provide an alternative cell source for applications in drug discovery and cell transplantation. In this review, we discuss different approaches to generate pluripotent stem cell-derived hepatocytes, advantages, limitations for each method and finally, how three-dimensional (3D) strategy can improve the maturation of PSCs -derived hepatocytes.  

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Journal title

volume 1  issue None

pages  110- 112

publication date 2017-10

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