A One-Pot Synthesis of Highly Functionalized Ketenimines by a Three-component 2-Thioxothiazolidin-4-one, Alkyl Isocyanides and Dialkyl Acetylenedicarboxylates

a one-pot synthesis of highly functionalized ketenimines by a three-component 2-thioxothiazolidin-4-one, alkyl isocyanides and dialkyl acetylenedicarboxylates

Microwave-Assisted Synthesis of Novel Functionalized Ketenimines and Azadienes via a Solvent-Free Reaction of Isatoic Anhydride, Alkyl-Isocyanides and Dialkyl Acetylenedicarboxylates

Ketenimines and azadienes are transient intermediates in organic chemistry especially in elimination-addition processes and in the formation of heterocyclic systems. These compounds play a considerable role as intermediates in the synthesis of heterocyclic ring systems. In this present research synthesis of novel ketenimines and azadienes via multicomponent reactions (MCRs...

A New synthesis of functionalized imidazo[2,1-b][1,3]thiazines with thiohydantoins, isocyanides and dialkyl acetylenedicarboxylates

The reaction of stoichiometric amounts of dialkyl acetylenedicarboxylates with alkyl isocyanides and 5,5-diaryl thiohydantoins in toluene and catalytic amount of p-TSA afforded imidazo[2,1-b][1,3]thiazines in good overall yields

One-pot Synthesis and Characterization of Highly Functionalized Thiazoles

A facile and efficient one-pot three-step process for the synthesis of 5-acetyl-2-imino-4-methylthiazoles via the cyclocondensation of 3-thiocyanatoacetylacetone with various hydrazine or hydrazide derivatives in EtOH has been developed. 3-Thiocyanatoacetylacetone itself has been synthesized as the intermediate from substitution reaction of thiocyanate with 3-chloroacetylacetone. B...

An Efficient Synthesis of 4H-chromene Derivatives by a One-pot, Three-component Reaction

A facile and efficient one-pot, multicomponent synthesis of 4H-chromenes is reported, through the reaction of arylglyoxalmonohydrates with 1,3-diketones and malononitrile in eTEMPthanol in the presence of L-proline as a catalyst.

A Novel Synthesis of Highly Functionalized Pyridines by a One-Pot, Three-Component Tandem Reaction of Aldehydes, Malononitrile and N-Alkyl-2-cyanoacetamides under Microwave Irradiation.

A convenient, fast and environmentally benign procedure for the synthesis of a new series of highly functionalized N-alkylated pyridines as privileged medicinal scaffolds was developed via a unique three-component reaction of easily available aromatic as well as heteroaromatic aldehydes, N-alkyl-2-cyanoacetamides and malononitrile in EtOH in the presence of K₂CO₃ as a base promoter under microw...