A New Approach to Virulence Factors of Candida albicans: From Gene to Function

Authors

  • Bagheri, Soghra MSc Student in Medical Mycology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  • Davari, Amirhossein MSc Student in Medical Mycology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  • Nabili, Mojtaba Assistant Professor, Faculty of Medicine, Sari Branch, Islamic Azad University, Sari, Iran
  • Ahmadkhani, Fardin MSc Student in Medical Mycology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  • Jafarzadeh, Jalal MSc Student in Medical Mycology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  • Mirzakhani, Roghayeh MSc Student in Medical Mycology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
  • Moazeni, Maryam Assistant Professor, Department of Medical Mycology and Parasitology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran Invasive Fungi Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  • Roodgari, Somayeh MSc Student in Medical Mycology, Student Research Committee, Mazandaran University of Medical Sciences, Sari, Iran
Abstract:

Recently, there is an increasing trend in the diversity of pathogenic yeasts isolated from clinical samples. However, Candida albicans is even now the major cause of yeast infections. Candida albicans is one of the members of the mucosal microbiota which can cause cutaneous, mucosal, and disseminated invasive infections in susceptible individuals. For persistence in the host, the yeast must have the ability to adhere to both biotic and abiotic surfaces following host tissue invasion, and obtain iron. One of the important properties of this pathogenic yeast is dimorphism which is its ability to switch from a unicellular to a hyphal mode of growth. Dimorphism is triggered in response to certain environmental conditions, such as pH alternation, temperature, or serum availability. These changes which allow the yeast to invade are associated with the expression of several genes involving in its pathogenesis, including SAP genes family encoding the secreted aspartic proteinases (Saps), the agglutinin-like sequence (ALS) family encoding the adhessive proteins, and phenotypic and morphologic switching systems. This review aimed at summarizing recent data on the regulation and relevant signal transduction of some important essential genes associated with virulence factors in Candid albicans. Surely, understanding the genetic of the virulence factors would be of great benefit in effective combating the yeast and also in designing new antifungal agents.  

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Journal title

volume 29  issue 178

pages  181- 196

publication date 2019-11

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