A comparison of pattern of psychiatric symptoms in inpatients with bipolar disorder type one with & without methamphetamine use

Background: Iran is facing an outbreak of methamphetamine-induced disorders and frequent use of these substances in patients with bipolar disorder. Using or intoxication of methamphetamine in patients with bipolar I disorder may alter the patient's clinical profile; however there is limited studies about impact of methamphetamine on clinical manifestation of bipolar disorders. This study aimed to compare psychiatric symptoms in patients with bipolar I disorder with and without concomitant use of methamphetamine. &nbsp; Methods: In a cross-sectional study, psychiatric symptoms of bipolar I disorder in patients with (Meth+) and without (Meth-) methamphetamine use was evaluated. A number of 57 participants with Meth + and 50 subjects with Meth- were recruited. The clinical picture of bipolar disorder was investigated by Young Mania Rating Scale (YMRS), 17-item Hamilton Depressive Rating Scale (HDRS-17) and the Scale for Assessment of Positive Symptoms (SAPS). Statistical comparisons were performed using the T-test for independent samples and Mann-Whitney test. &nbsp; Results: There was no statistically significant difference between two groups regarding age, duration of illness and hospitalizations. However, male participants were significantly higher in Meth+ group than in Meth- one (p<0.001). The mean (&plusmn; SD) scores in the two groups of&nbsp; Meth+ and Meth-&nbsp; for YMRS, HDRS, and SAPS were 31.3 (&plusmn;1.3) and 34.0 (&plusmn;1.2), 13.7 (&plusmn;0.7) and 13.5&plusmn;(0.5), and 50.0 (&plusmn;1.9) and&nbsp; 48.0 (&plusmn;2.1), respectively, which were not statistically significant (p<0.05). &nbsp;&nbsp;Conclusion: There was no significant difference in the overall clinical manifestation of bipolar I disorder in patients with and without methamphetamine use. However, in some symptomatology domains, there were some differences between the two groups.