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Effect of neoadjuvant chemoradiotherapy on angiogenesis in oesophageal cancer (Br J Surg 2003; 90: 1373-1378).
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A complicating factor in the translational pharmacology of sphingosine 1-phosphate agonists is that they exert their pharmacological effect through their respective phosphate metabolites, which are formed by the enzyme sphingosine kinase (S1PHK). In this investigation, we present a semimechanistic pharmacokinetic model for the interconversion of S1PHK substrates and their respective phosphates ...
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full textMolecules 2000, 5, 1372-1378
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volume 5 issue None
pages 9- 15
publication date 2000-12
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