ویژگیهای‌حج سال 1371

NpgRj_Ng_1685 1367..1371

The structure of a protein depends critically on the complex interactions among its amino acid residues. It has long been hypothesized that interacting residues might tend to coevolve, but it is not known whether such coevolution is a general phenomenon across the proteome. Here, we describe a novel methodology called phylogeny-aided structural analysis, which uncovers robust signals of interac...

Op-brai130031 1371..1382

1 Department of Neurology, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan 2 Stroke Centre, Aichi Medical University, Aichi 480-1195, Japan 3 Laboratory for Motor Neuron Disease, RIKEN Brain Science Institute, Wako, Saitama 351-0198, Japan 4 CREST, Japan Science and Technology Agency, 4-1-8, Honcho, Kawaguchi, Saitama 332-0012, Japan 5 Department of Neurology, Kyoto Univer...

Dmd062745 1360..1371

Effective treatments for primary brain tumors and brain metastases represent a major unmet medical need. Targeting the CDK4/CDK6cyclin D1-Rb-p16/ink4a pathway using a potent CDK4 and CDK6 kinase inhibitor has potential for treating primary central nervous system tumors such as glioblastoma and some peripheral tumors with high incidence of brain metastases. We compared central nervous system exp...

1371-78; CHI Nov00 77478 (Mes)

Objective: To examine a wide range of parentand teacher-reported behaviors in relation to child-reported depression and anxiety in preadolescence. Method: Subjects were participants in a longitudinal study of 420 preschool children from the general population that started in 1989. At second follow-up 8 years later (ages 10–11 years), usable parent information was obtained for 358 children. For ...

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