نقش رسپتورهای شناساگر الگو (PRR) در ابتلا به عفونت های کاندیدایی در انسان
Authors
Abstract:
Candida species are medically significant yeast that can cause different infection ranging from mild mucosal to disseminated infection. Invasive and sever mucosal infections are often life threatening disorders, especially in immunocompromised hosts due to immunodeficiency either in adaptive or innate immunity which are susceptible to candidiasis. Nevertheless, not all of them are susceptible to candidiasis which shows that genetic variation and polymorphism in immune system can play a crucial role in infection. Although genetic variation occurs rarely in human’s genome, it has a significant role in susceptibility to fungal infections. For example, genetic variation in coding genes of PRRs (TLR2, TLR4, Dectin I, Dectin II, and NLRp3) is correlated with susceptibility to candidiasis. Results have shown polymorphisms in genes that are involved in host defense against Candida infection. Therefore, genetic and immunological studies are highly necessary to understand the pathogenesis. Recently several studies have been performed on host defense against Candida infections which might be useful in the diagnosis and treatment of fungal infections. This paper represents a comprehensive overview of genetic susceptibility in human’s Candida infection.
similar resources
نقش رسپتورهای شناساگر الگو (prr) در ابتلا به عفونت های کاندیدایی در انسان
کاندیدا از لحاظ پزشکی قارچ مهمی است که طیفی از عفونت های مخاطی تا عفونت های سیستمیک و تهاجمی را در انسان ایجاد می نماید. عفونت های تهاجمی و عفونت های مخاطی شدید اغلب تهدیدکننده زندگی و در افرادی که دچار نقص سیستم ایمنی هستند رخ می دهد. این افراد استعداد ابتلا به عفونت های کاندیدایی را به علت کاهش توانایی سیستم ایمنی اکتسابی یا ذاتی برای مقابله با عامل عفونی از جمله کاندیدا را دارند. با این وجود...
full textاثر بربرین در تنظیم آستروسیتهای Gfap+ ناحیه هیپوکمپ موشهای صحرایی دیابتی شده با استرپتوزوتوسین
Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...
full textاثر بربرین در تنظیم آستروسیتهای Gfap+ ناحیه هیپوکمپ موشهای صحرایی دیابتی شده با استرپتوزوتوسین
Background: Diabetes mellitus increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. Berberine, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Moreover astrocytes are proving critical for normal CNS function, and alterations in their activity...
full textبررسی ضایعات لیکنوئید دهان وشیوع عفونت کاندیدایی در آنها
Normal 0 false false false EN-US X-NONE AR-SA 50 patients with oral lichenoid lesions who had oral candidiasis were selected for clinical examination and histopathologic evaluation. Inclusion criteria were reticular lichenoid lesions or any erosive, atrophic, bullouse or plaque-like changes with any reticular view. Medical and dental history and re...
full textعفونت کاندیدایی دستگاه ادراری؛ پروتکل درمانی
Background and purpose: The choice of antifungal agent in treatment of Candida urinary tract infections (CUTI) is dependent on the site of infection, the underlying disease of the patient, and the pharmacokinetics/pharmacodynamics (PK/PD) of the agent. This study aimed to perform a review of antifungal therapy for CUTI. Materials and methods: Data was obtained by a search for full-text artic...
full textMy Resources
Journal title
volume 24 issue 116
pages 224- 240
publication date 2014-09
By following a journal you will be notified via email when a new issue of this journal is published.
No Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023