تشخیص عفونت هلیکوباکترپیلوری در بیماران مبتلا به زخم معده با استفاده از آزمایش‌های سرولوژی و آنتی‌ژن مدفوعی

ABSTRACT Background & Objectives: Helicobacter pylori is a gram negative, microaerophilic and flagellated bacillus, which causes digestive diseases, such as peptic ulcer and gastric cancer. This study aimed to detect Helicobacter pylori in patients with ulcer disease through stool antigen and serological tests in Sari, Iran. Materials and Methods: In this study, 120 patients (aged 15-66 years) with symptoms of peptic ulcer referring to the gastroenterology clinic were selected . H. pylori antigen stool, as well as IgG and IgA antibodies produced against this bacterium were determined in patients. Results: In this study, nine (7.5%) patients were regarded as negative for H. pylori, six (5%) individuals were suspected and 105 (87.5%) cases were positive. Moreover, participants with negative stool antigen were also negative in terms of IgA antibody. However, patients with suspected stool antigen were IgG positive. Frequency of IgA and IgG was reported to be 32 (26.6%) and 102 (85%) cases, respectively. Conclusion: According to the results of this study, H. pylori stool antigen test is a non-invasive procedure, which could be applied as a valid diagnostic method.