بررسی نسبت LH و FSH سرم به مایع کیست تخمدان در توده‏های تخمدانی

Abstract Backgraound: Regarding the prevalence and high mortality rate of ovarian cancers, importance of markers to determine ovarian malignancies earlier, considerable experimental evidence about serum Gonadotropins to cyst fluid ratio with pathology of ovarian tumors and finally not enough experiments in our country, the present study was performed in Imam Hossein hospital between 2008 and 2010. Methods: This study was cross-sectional and performed in patients operated because of ovarian mass. Their serum samples and cyst fluid obtained at the time of laparatomy and histopathologic diagnosis was established after removal of the tumor. FSH and LH concentration were measured in serum and tumor fluid based on Microparticle Enzyme Immunoassay technology in Imam Hossein laboratory. Ratios of them were determined in four pathologic groups (simple cyst, benign, borderline and malignant) and statistical comparison was done with the Kruskal-Wallis and Mann-Whitney U-test. Results: We studied 100 patients with ovarian mass but pathology of 79 patients was epithelial tumors and simple cysts. The most common mass were simple cysts (48.1%) and then benign tumors (27.8%), malignant tumors (16.5%) and borderline tumors (7.6%). Serum FSH / tumor fluid ratios were in simple cysts (21.1±53.8), benign tumors (50.7±174.9), borderline tumors (1.5±0.7) and malignant tumors (1.9±1.9) (P<0.001) and serum LH/tumor fluid ratios were in simple cysts (12.1±26.5), benign tumors (20.0±29.1), borderline tumors (2.6±2.3) and malignant tumors (2.8±3.7) (P<0.002). Conclusion: Our findings suggest that serum gonadotropins / tumor fluid ratio can be used as a tumor marker for identification of ovarian tumors. Also serum gonadotropins / tumor fluid ratio could be of value in differential diagnosis of ovarian tumors after determination normal and abnormal cut off point and ratios of them. Keywords: Ovarian epithelial tumor, Simple cyst, Gonadotropin, Ovarian tumor fluid.