بررسی شیوع هپاتیت دارویی و عوامل مرتبط با آن در بیماران مبتلا به سل مراجعه کننده به بیمارستان رازی در طی سال های 1385 تا 1390

Background and purpose: Hepatotoxicity and elevated serum aminotransferase is a severe side effect of anti-Tuberculosis therapy and some cases could even develop hepatitis. This study aimed at determining the prevalence of drug induced hepatitis and predisposing factor after anti-Tuberculosis therapy in Razi hospital. Materials and methods: In this cross-sectional study we used the medical records of all confirmed cases of tuberculosis admitted at the infectious disease ward of Ghaemshahr Razi hospital between 2006-2011. Variables included age, sex, type of TB, other medications, basal levels of liver enzymes, enzyme changes during treatment, and co-infection (such as hepatitis B - HIV). The diagnosis of drug induced hepatitis was done with at least five-fold increase of aminotransferase levels. Data was analyzed using SPSS17, chi square tests and Fisher's exact test. Results: Of 230 patients, 56.5% were male. The frequency of pulmonary TB and extra pulmonary TB was 91.7% and 8.3%, respectively. Standard treatment was used in 92.5% of patients with tuberculosis. 23.5% of patients had an underlying disease. Prevalence of drug-induced hepatitis in this study was 9.5%. There was no significant correlation between gender, type of tuberculosis and type of drug treatment with drug-induced hepatitis, but there was a significant relationship between age and druginduced hepatitis. Conclusion: The results showed that old age was the only significant risk factor for druginduced hepatitis in the treatment of tuberculosis, hence, elderly patients must be placed under regular clinical and laboratory evaluation.