بررسی سطح سرمی 25- هیدروکسی ویتامین- د، کلسیم، فسفر و آلکالن فسفاتاز در کودکان مبتلا به صرع تحت درمان با داروهای ضد تشنج
Authors
Abstract:
Background: Epilepsy is a common disease in the pediatric neurology. There are frequent anti-epileptic drugs which are used in management of epilepsy. Anti-epileptic drugs may have some complications on bone and vitamin-D metabolism. In this study we aimed to evaluate vitamin-D metabolism in epileptic children.Methods: The study was a prospective and cross sectional one. A total 89 epileptic children who were taking anti-epileptic drugs for longer than six months with no underlying disorder in Imam Khomeini and Bahrami Hospitals in Tehran, Iran were enrolled in our studyResults: Forty nine boys and 40 girls were enrolled in this study mean age of the patients was 7.8±2.1 years. Mean duration of anti-epileptic drug therapy was 2.3 years (SD=0.4), 70 of patients were under monotherapy and 19 were under polytherapy. None of the patients had signs of rickets. Serum calcium and phosphor levels were within normal ranges. Serum alkaline phosphates levels were increased more than two times in 43%. 42% had vitamin-D deficiency (25-OH Vit D<10 ng/ml) and another 33% had vitamin-D insufficiency (10<25-oh Vit D<20 ng/ml). 29 patients (32%) were taking prophylactic supplemental Vit D (200-400 IU/day). There was significant difference between patients taking supplemental vitamin-D as prophylaxis and patients who did not (p=0.04). There was no significant difference in vitamin-D levels between patients according to age, gender or different drugs.Conclusion: Periodic measurement of 25-hydroxy vitamin-D is recommended in epileptic children taking anti-epileptic dugs. Supplemental vitamin-D administration in such patients may be helpful.
similar resources
مقایسه تأثیر وضعیت طاق باز و دمر بر وضعیت تنفسی نوزادان نارس مبتلا به سندرم دیسترس تنفسی حاد تحت درمان با پروتکل Insure
کچ ی هد پ ی ش مز ی هن ه و فد : ساسا د مردنس رد نامرد ي سفنت سرتس ي ظنت نادازون داح ي سکا لدابت م ي و نژ د ي سکا ي د هدوب نبرک تسا طسوت هک کبس اـه ي ناـمرد ي فلتخم ي هلمجزا لکتورپ INSURE ماجنا م ي دوش ا اذل . ي هعلاطم ن فدهاب اقم ي هس عضو ي ت اه ي ندب ي عضو رب رمد و زاب قاط ي سفنت ت ي هـب لاتـبم سراـن نادازون ردنس د م ي سفنت سرتس ي لکتورپ اب نامرد تحت داح INSURE ماجنا درگ ...
full textبررسی سطح سرمی 25 هیدروکسی ویتامین D در شیرخواران مبتلا به برونشیولیت
Background: Bronchiolitis is one of the most common diseases of the lower respiratory tract in infants. Vitamin D has been shown to be protective against lower respiratory infections; however, there are limited and contradictory results in relation to serum vitamin D level and the incidence of bronchiolitis in children. The aim of this study was to compare serum levels of this vitamin in health...
full textبررسی تاثیر تجویز دوزهای بالای ویتامین D3 خوراکی بر سطح فسفاتاز قلیایی، کلسیم، فسفر و ویتامین D3 سرم کودکان بالای 3 سال تحت درمان با فنوباربیتال
Background and Objective: Chronic use of antiepileptic drugs may influence the bones and their mineral metabolism due to deficiency of vitamin D3. In this study we investigated the effect of high dose vitamin D3 on bones and their mineral metabolism. Materials and Methods: Fifty six children older that 3 years old who were affected by epilepsy and had taken the antiepileptic drugs at least for ...
full textبررسی سطح کلسیم، فسفر و آلکالن فسفاتاز سرم در سه ماهه های مختلف حاملگی
مقدمه: اسکلت جنین درحین حاملگی شکل می گیرد و کلسیم و فسفر مورد نیاز به وسیله مادر تامین می شود. بنابراین، تغییرات چشمگیری ممکن است در اسکلت مادر رخ دهد. این مطالعه برای ارزیابی تغییرات مارکرهای خونی و ادراری استخوان سازی و جذب استخوان درحین حاملگی انجام شد. روش کار : این مطالعه مورد شاهدی از مهرماه 1384- مرداد 1385 بر 307 زن حامله در بیمارستان امام رضا (ع) مشهد انجام شد. کلسیم، فسفر، آلکالن...
full textتعیین رابطه سطح سرمی کلسیم، فسفر، آلکالن فسفاتاز با ضایعات جاینت سل گرانولومای محیطی در مبتلایان ایرانی، 78-1377
Peripheral giant cell granuloma (P.G.C.G) is an exophytic lesion with an approximate size of 0.5-1.5 mm. It usually occurs on gingival and alveolar ridge of mandible particularly in molar and premolar region. The relation of serum calcium (Ca), Phosphor (P), and alkaline phosphatase (Alk) levels to P.G.C.G is yet controversial. In this descriptive study, 33 patients with P.G.C.G were chosen and...
full textبررسی سطح سرمی 25- هیدروکسی ویتامین D در کودکان دچار سوختگی بستری در بیمارستان شهید مطهری
Material and Methods: In this analytical cross-sectional study which was done in children ward of burn injury hospitals in 2012- 2014, 118 patients were studied. A checklist consists of age, sex, the degree burns, entire surface of burn, serum level of 25-OH-VitD, total protein, albumin, phosphorus, calcium, ionized and total calcium and PTH conducted. Data were entered into SPSS v.16 and analy...
full textMy Resources
Journal title
volume 68 issue None
pages 590- 594
publication date 2011-01
By following a journal you will be notified via email when a new issue of this journal is published.
No Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023