بررسی ارتباط بین پلی‌مورفیسم GSTP1 Ile105Val و خطر اندومتریوز در یک جمعیت ایرانی
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Abstract:
Introdution: Endometriosis is one of the most common gynecologic disorders and shows significantly elevated prevalence in industrial regions. Additionally, a possible genetic predisposition is assumed for the disease. Glutathione S-transferases (GSTs) are enzymes participated in the metabolism of many human disease-causing mutagens, carcinogens and environmental pollutants. A functionally significant A to G transition in GSTP1 gene causes substitution of in the codon 105 can influence the enzyme activity. The aim of the present study was to investigate association of GSTP1 polymorphism and endometriosis in women from central and southern Iran. Methods: In this case-control study, after obtaining informed consent, samples were obtained from 101 endometriosis patients and 126 healthy controls. Genomic DNA was isolated from peripheral blood cells and genotyping was performed using polymerase chain reaction followed by restriction fragment length polymorphism (PCR-RFLP) analysis. Data were compared in both groups by using Pearson chi-square and Hardy-Weinberg equilibrium tests. Results: Results showed no significant association between GSTP1 Ile105Val Polymorphism and endometriosis susceptibility (P = 0.370). Frequencies of the AA, AG and GG genotype of GSTP1 gene polymorphism in the patients were 42.6%, 47.5% and 9.9%, while the frequencies in the controls were 49.2%, 45.2% and 5.6%, respectively. Conclusion: According to our study, GSTP1 Ile105Val polymorphism appears to be not associated with the risk of endometriosis in the studied population. However, additional studies, especially with larger sample size are needed to validate these findings.
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Journal title
volume 26 issue 1
pages 55- 63
publication date 2018-04
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