اثر هشت هفته تمرینات ترکیبی بر توان هوازی و سطح سرمی‌پروتئین سرکوب‌گر تومور P53 در بیماران مبتلا به سرطان پروستات: یک کارآزمایی بالینی

Background and Objectives: Physical activity plays a useful role in maintaining and improving the quality of life of men suffering from prostate cancer. The presence of tumor suppressor proteins including P53 is one of the regulatory mechanisms in controlling the progression of the disease. The purpose of this study was to investigate the effect of eight-week concurrent training on aerobic capacity and serum levels of P53 tumor suppressor protein in patients with adenocarcinoma type of prostate cancer. Materials and Methods: In this clinical trial study, the statistical population included prostate cancer patients with adenocarcinoma-type T1 and T2 stages referred to Baqiyatallah El-Azam Subspeciality Hospital in Tehran from late March to late September  2016. The sample size included 20 men who were randomly divided into control (n=10) and experimental (n=10) groups. The experimental group performed concurrent training for eight weeks (three days per week), including resistance training with 60-75 percent of a maximal repeat and aerobic exercise with 60-75 percent of maximum heart rate. The control group did not receive any intervention. The serum level of P53 was measured by ELISA method and analyzed by independent t-test and paired t-test. Results: The results showed a significant increase in the maximum aerobic capacity (p<0.001) and serum level of P53 (p=0.029), and a significant decrease in body mass index (p<0.001) in the experimental group compared to the control group. Conclusion: The results indicated that the concurrent training has caused the level of P53 tumor suppressor protein to be increased and possibly in this way can  reduce the progression of adenocarcinoma cancer tumors. Key words: Concurrent training, Prostate cancer, P53 tumor suppressor protein   Funding: This study did not have any funds. Conflict of interest: None declared. Ethical approval: The Ethics Committee of Shahid Beheshti University of Medical Sciences approved the study (IR.SBMU.RETECH.REC1396.819).     How to cite this article: Asghari Rakabdarkolaee M, Barari A, Abdi A, Hasrak K. The Effect of Eight-Week Concurrent Training on Aerobic Capacity and Serum Level of P53 Tumor Suppressor Protein in Prostate Cancer Patients: A Clinical Trial. J Rafsanjan Univ Med Sci 2018; 17 (8): 731-44. [Farsi]